原位鳞状细胞癌/光化性角化病及浸润性鳞状细胞癌患者的HLA抗原谱差异：浸润性鳞状细胞癌发生是否存在遗传易感性？

HLA Antigen Profile Differences in Patients with SCC (Squamous Cell Carcinoma) In-Situ /Actinic Keratosis and Invasive SCC: Is There a Genetic Succeptibility for Invasive SCC Development?

作者信息

Atasoy Mustafa, Anadolu-Braise Rana, Pirim Ibrahim, Dogan Hasan, Ikbal Mevlüt

机构信息

Atatürk University, Faculty of Medicine, Department of Dermatology, Erzurum, Turkey.

Ankara University, Faculty of Medicine, Department of Dermatology, Ankara, Turkey.

出版信息

Eurasian J Med. 2009 Dec;41(3):162-4.

PMID:25610095

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4261280/

Abstract

OBJECTIVE

Actinic keratoses (AK) are proliferation of neoplastic keratinocytes confined to the epidermis induced by damaging solar ultraviolet radiation (UVR). When the neoplastic keratinocytes extend in to papillary-reticular dermis, then the lesion termed as squamous cell carcinoma (SCC). We have compared HLA class I and II antigen profiles in three patient groups namely: AK (n: 31) (patients without past or present invasive SCC), invasive SCC (n: 38), and SCC derived from / inconjuction with AK (n: 11).

MATERIALS AND METHODS

Low-resolution typing for the HLA-A, B, C and HLA-DR/DQ was performed by means of the PCR-sequence specific primer (PCR-SSP) method using SSP HLA class I generic DNA Typing Tray.

RESULTS

HLA results of these three groups were compared with the healthy control group (n: 100). There were not significant difference in HLA class I and II antigen profiles in AK group compared to the control. Whereas HLA-A2 allele (60.52%, p=0.016, OR=2.726, 95%CI=1.265-5.876), HLA-B60 (13.15%, p=0.025, OR=7.424, 95%CI=1.375-40.099) were higher in SCC group than the control. HLA-B51 allele (72.72%, p=0.008, OR=6.853, 95%CI=1.696-27.720) distribution were more common in SCC derived from AK than the control.

CONCLUSIONS

Historically, AKs have been characterized as premalignant. It has, however, been considered that AK and SCC represent the same disease process at the different stages of evaluation. Clinically, and histopathologically it is difficult to determine where AK ends and invasive SCC begins. From dermatopathological point of view AK is clearly SCC in-situ, however although AK is a common lesion in Caucasians, not all AKs develop in to invasive SCC, at least not with the same biological pace. We concluded that genetic differences such as HLA class I and II distribution between AK and SCC may not seem to play susceptibility role for invasive SCC development.

摘要

目的

光化性角化病（AK）是由有害的太阳紫外线辐射（UVR）诱导的局限于表皮的肿瘤性角质形成细胞增殖。当肿瘤性角质形成细胞延伸至乳头-网状真皮时，该病变称为鳞状细胞癌（SCC）。我们比较了三组患者的HLA I类和II类抗原谱，即：AK组（n = 31）（无既往或当前侵袭性SCC的患者）、侵袭性SCC组（n = 38）以及源自AK或与AK相关的SCC组（n = 11）。

材料和方法

使用SSP HLA I类通用DNA分型板，通过PCR序列特异性引物（PCR-SSP）方法对HLA-A、B、C以及HLA-DR/DQ进行低分辨率分型。

结果

将这三组患者的HLA结果与健康对照组（n = 100）进行比较。与对照组相比，AK组的HLA I类和II类抗原谱无显著差异。而SCC组的HLA-A2等位基因（60.52%，p = 0.016，OR = 2.726，95%CI = 1.265 - 5.876）、HLA-B60（13.15%，p = 0.025，OR = 7.424，95%CI = 1.375 - 40.099）高于对照组。源自AK的SCC组中HLA-B51等位基因（72.72%，p = 0.008，OR = 6.853，95%CI = 1.696 - 27.720）的分布比对照组更常见。

结论

从历史上看，AK一直被视为癌前病变。然而，有人认为AK和SCC在评估的不同阶段代表相同的疾病过程。在临床和组织病理学上，很难确定AK何时结束以及侵袭性SCC何时开始。从皮肤病理学角度来看，AK显然是原位SCC，然而，尽管AK在白种人中是常见病变，但并非所有AK都会发展为侵袭性SCC，至少其生物学进程不同。我们得出结论，AK和SCC之间的遗传差异，如HLA I类和II类分布，似乎在侵袭性SCC的发生中不发挥易感性作用。