Kaloglu Songul, Guraslan Hakan, Tekirdag Ali Ismet, Dagdeviren Hediye, Kaya Cihan
Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Eurasian J Med. 2014 Oct;46(3):164-8. doi: 10.5152/eajm.2014.47. Epub 2014 Aug 26.
We aimed to evaluate the predictive value of preoperative thrombocytosis for postoperative tumor stage and tumor grade in patients with endometrial cancer.
This was a retrospective study carried out in our gynecologic oncology department between January 2000 and December 2011. We reviewed the medical charts of 190 patients diagnosed with endometrial carcinoma and underwent complete staging procedure. The clinicopathologic characteristics of the patients such as; age, gravidity, parity, menopausal status, body mass index, co-morbidities (diabetes, hypertension etc.), stage, grade, histological subtype, depth of myometrial invasion, peritoneal washing cytology and preoperative platelet count were recorded. Endometrioid adenocarcinomas were graded according to the FIGO classification. Blood samples for the measurement of platelet count were obtained 3 days prior to the surgery. Thrombocytosis was defined as a platelet count of 300×10(9)/L. P values less than 0.05 derived from two-tailed tests were considered statistically significant.
The mean age of the study population was 55.4 (range 33-80) years. The mean gravidity was 3.8 (range 0-12) and the mean parity was 3.32 (range 0-11). 108 (56,8%) patients were with body mass index of >30 kg/m(2). The mean platelet count among women was 288, 6±90.7×10(9)/L (range 105-772×10(9)/L). The majority of the patients were with early stage diseases during the surgeries. 170 (89.5%) of the patients had stage I to II disease, and 20 (10.5%) of them had stage III to IV disease. There were no statistical significance between thrombocytosis and age, gravidity, parity, BMI, cancer grade and stage, histological subtype of the tumor, depth of invasion, cervical involvement, intrauterine tumor volume and peritoneal washing cytology.
We found that preoperative platelet count was not correlated with the stage or grade of endometrial cancer.
我们旨在评估子宫内膜癌患者术前血小板增多症对术后肿瘤分期和肿瘤分级的预测价值。
这是一项于2000年1月至2011年12月在我们妇科肿瘤科进行的回顾性研究。我们回顾了190例被诊断为子宫内膜癌并接受完整分期手术患者的病历。记录了患者的临床病理特征，如年龄、妊娠次数、产次、绝经状态、体重指数、合并症（糖尿病、高血压等）、分期、分级、组织学亚型、肌层浸润深度、腹腔冲洗细胞学检查和术前血小板计数。子宫内膜样腺癌根据国际妇产科联盟（FIGO）分类进行分级。手术前3天采集用于测量血小板计数的血样。血小板增多症定义为血小板计数≥300×10⁹/L。来自双侧检验的P值小于0.05被认为具有统计学意义。
研究人群的平均年龄为55.4岁（范围33 - 80岁）。平均妊娠次数为3.8次（范围0 - 12次），平均产次为3.32次（范围0 - 11次）。108例（56.8%）患者体重指数>30 kg/m²。女性的平均血小板计数为288.6±90.7×10⁹/L（范围105 - 772×10⁹/L）。大多数患者在手术期间处于早期疾病阶段。170例（89.5%）患者患有I至II期疾病，其中20例（10.5%）患有III至IV期疾病。血小板增多症与年龄、妊娠次数、产次、体重指数、癌症分级和分期、肿瘤组织学亚型、浸润深度、宫颈受累、子宫内肿瘤体积和腹腔冲洗细胞学检查之间无统计学意义。
我们发现术前血小板计数与子宫内膜癌的分期或分级无关。
