Arai T, Machida Y, Sasaki M, Oki Y
Department of Veterinary Biochemistry, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
Vet Res Commun. 1989;13(6):421-6. doi: 10.1007/BF00402563.
The activities of the hepatic glycolytic enzymes glucokinase (GKase) and hexokinase (HKase) in herbivorous Microtus arvalis were very low and the hepatic fructose-1,6-diphosphatase (FDPase) activities were almost the same as those in C57BL/6J mice. Glycosuria was observed in over 50% of voles fed on a low fibre, high concentrate diet. Voles with a high incidence of glycosuria for over 6 weeks became insulin deficient. In these diabetic voles, the hepatic GKase, HKase and FDPase activities decreased considerably as a result of diminished insulin secretion and fatty degeneration of the hepatic cells. It was considered that M. arvalis would be a useful animal model in which to study disorders of glucose utilization in herbivora.
草食性的田鼠肝脏中糖酵解酶葡萄糖激酶（GKase）和己糖激酶（HKase）的活性非常低，其肝脏果糖-1,6-二磷酸酶（FDPase）的活性与C57BL/6J小鼠几乎相同。超过50%以低纤维、高浓缩饲料喂养的田鼠出现了糖尿。连续6周以上糖尿发生率高的田鼠出现胰岛素缺乏。在这些糖尿病田鼠中，由于胰岛素分泌减少和肝细胞脂肪变性，肝脏GKase、HKase和FDPase的活性显著降低。人们认为，田鼠将是研究草食动物葡萄糖利用紊乱的一种有用的动物模型。
