调节内皮通透性的机制。
Mechanisms regulating endothelial permeability.
作者信息
Sukriti Sukriti, Tauseef Mohammad, Yazbeck Pascal, Mehta Dolly
机构信息
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois, USA.
出版信息
Pulm Circ. 2014 Dec;4(4):535-51. doi: 10.1086/677356.
Abstract
The endothelial monolayer partitioning underlying tissue from blood components in the vessel wall maintains tissue fluid balance and host defense through dynamically opening intercellular junctions. Edemagenic agonists disrupt endothelial barrier function by signaling the opening of the intercellular junctions leading to the formation of protein-rich edema in the interstitial tissue, a hallmark of tissue inflammation that, if left untreated, causes fatal diseases, such as acute respiratory distress syndrome. In this review, we discuss how intercellular junctions are maintained under normal conditions and after stimulation of endothelium with edemagenic agonists. We have focused on reviewing the new concepts dealing with the alteration of adherens junctions after inflammatory stimulus.
摘要
内皮单层将血管壁中的组织与血液成分分隔开来，通过动态打开细胞间连接来维持组织液平衡和宿主防御。致水肿激动剂通过信号传导使细胞间连接打开，从而破坏内皮屏障功能，导致间质组织中形成富含蛋白质的水肿，这是组织炎症的一个标志，如果不加以治疗，会导致致命疾病，如急性呼吸窘迫综合征。在这篇综述中，我们讨论了在正常条件下以及在用致水肿激动剂刺激内皮后，细胞间连接是如何维持的。我们重点回顾了关于炎症刺激后黏附连接改变的新概念。
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