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本文引用的文献

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Increasing prevalence of atrial fibrillation and flutter in the United States.美国心房颤动和房扑的患病率不断增加。
Am J Cardiol. 2009 Dec 1;104(11):1534-9. doi: 10.1016/j.amjcard.2009.07.022.
2
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study.心房颤动的患病率、发病率和终生风险：鹿特丹研究。
Eur Heart J. 2006 Apr;27(8):949-53. doi: 10.1093/eurheartj/ehi825. Epub 2006 Mar 9.
3
Amiodarone-induced angioedema: report of two cases.胺碘酮诱发的血管性水肿：两例报告。
Indian J Dermatol Venereol Leprol. 2005 Jan-Feb;71(1):46-7. doi: 10.4103/0378-6323.13789.
4
Amiodarone versus sotalol for atrial fibrillation.胺碘酮与索他洛尔治疗心房颤动的比较。
N Engl J Med. 2005 May 5;352(18):1861-72. doi: 10.1056/NEJMoa041705.
5
Use of amiodarone for atrial fibrillation in patients with preexisting pulmonary disease in the AFFIRM study.在AFFIRM研究中，胺碘酮用于已有肺部疾病的心房颤动患者。
Am J Cardiol. 2005 Feb 1;95(3):404-5. doi: 10.1016/j.amjcard.2004.09.044.
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Thyroiditis.甲状腺炎
N Engl J Med. 2003 Jun 26;348(26):2646-55. doi: 10.1056/NEJMra021194.
7
Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter.心房颤动或心房扑动患者门诊启动抗心律失常药物临床路径的安全性和可行性
Am J Cardiol. 2003 Jun 15;91(12):1437-41. doi: 10.1016/s0002-9149(03)00395-3.
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AGA technical review on nonalcoholic fatty liver disease.美国胃肠病学会关于非酒精性脂肪性肝病的技术审查
Gastroenterology. 2002 Nov;123(5):1705-25. doi: 10.1053/gast.2002.36572.
9
Amiodarone-induced angioedema.胺碘酮所致血管性水肿。
Allergy. 2000 Dec;55(12):1199-200. doi: 10.1034/j.1398-9995.2000.00824.x.
10
Practical guidelines for clinicians who treat patients with amiodarone. Practice Guidelines Subcommittee, North American Society of Pacing and Electrophysiology.给使用胺碘酮治疗患者的临床医生的实用指南。北美心脏起搏与电生理学会实践指南小组委员会。
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一名新发房颤患者急性起病的胺碘酮诱发的血管性水肿。

Acutely onset amiodarone-induced angioedema in a patient with new atrial fibrillation.

作者信息

Vakili Hossein, Khaheshi Isa, Memaryan Mehdi, Haybar Habib, Esmaeeli Shooka

机构信息

Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

Case Rep Emerg Med. 2014;2014:321587. doi: 10.1155/2014/321587. Epub 2014 Dec 25.

DOI:10.1155/2014/321587
PMID:25610669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4291005/
Abstract

A 50-year-old man was admitted to our emergency department due to new episode of palpitation. He had history of angioplasty of right coronary artery (RCA) with drug eluting stent 2 years ago. His electrocardiogram revealed atrial fibrillation (AF). Intravenous amiodarone 150 mg during 10 minutes and then 1 mg/min infusion were started to achieve rate control and pharmacologic conversion to sinus rhythm. After 60 minutes of starting amiodarone infusion, he developed swelling of the skin around his mouth and eyes, and also mucosa of the mouth, eyes and tongue. To conclude, angioedema should be considered a rare side effect of amiodarone which is used broadly in cardiovascular field.

摘要

一名50岁男性因新发心悸发作被收入我院急诊科。他2年前有右冠状动脉（RCA）药物洗脱支架血管成形术史。他的心电图显示为心房颤动（AF）。开始静脉注射胺碘酮150毫克，持续10分钟，然后以1毫克/分钟的速度输注，以实现心率控制并药物转复为窦性心律。在开始胺碘酮输注60分钟后，他出现了口周和眼部周围皮肤以及口腔、眼睛和舌头黏膜的肿胀。总之，血管性水肿应被视为胺碘酮的一种罕见副作用，胺碘酮在心血管领域广泛使用。