参松养心胶囊治疗老年冠心病心律失常的疗效与安全性：系统评价与Meta分析方案
Efficacy and safety of Shen-Song-Yang-Xin capsule for treating arrhythmia in the elderly patients with coronary heart disease: Protocol for a systematic review and meta-analysis.
作者信息
Zeng Zhicong, Zhuang ZhenJie, He YingXian, Yang ZhaoJun, Song Yinzhi
机构信息
Guangzhou University of Chinese Medicine, Guangzhou.
Baoan Hospital of Traditional Chinese Medicine in Shenzhen, Shenzhen, China.
出版信息
Medicine (Baltimore). 2018 Dec;97(51):e13599. doi: 10.1097/MD.0000000000013599.
BACKGROUND
Coronary heart disease (CHD) is a major cause of mortality worldwide. Shen-Song-Yang-Xin capsule (SSYXC) has received extensive attention as an alternative therapy in improving myocardial ischemia and hypoxia effectively. In addition, there has been no systematic review or meta-analysis of SSYXC in the treatment of the elderly patients with cardiac arrhythmias in coronary heart disease (CHD). Therefore, we carry out a protocol of a proposed study based on the referred Reporting Items for Systematic Reviews and Meta-Analyses guidelines that aims to systematically evaluate the efficacy and safety of SSYXC in the elderly patients with cardiac arrhythmias in CHD.
METHODS
Two researchers will search 9 electronic databases (PubMed, Medline, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Database) to identify all studies that meet the inclusion criteria and were published before October 2018. The literature selection process will be reported in accordance with the PRISMA guidelines. After information extraction and methodological quality evaluation, we will use Stata 12.0 software (STATA Corporation, College Station, TX) to synthesize the data. The primary outcomes will include effective rates of treatment and improvements of electrocardiogram or 24 hours dynamic electrocardiogram result, and secondary outcomes will include improvement of relevant serological indexes, heart function classification and adverse events.
RESULTS
The data synthesis results will objectively illustrate the efficacy and safety of SSYXC in the elderly patients with cardiac arrhythmias in CHD.
CONCULSION
The findings will provide a reference for the use of SSYXC in the treatment of the elderly patients with cardiac arrhythmias in CHD.
REGISTRATION
PROS-PERO CRD42018112570.
背景
冠心病（CHD）是全球主要的死亡原因。参松养心胶囊（SSYXC）作为一种能有效改善心肌缺血缺氧的替代疗法受到了广泛关注。此外，目前尚无关于参松养心胶囊治疗冠心病老年心律失常患者的系统评价或荟萃分析。因此，我们根据系统评价和荟萃分析报告项目指南开展一项拟议研究的方案，旨在系统评价参松养心胶囊治疗冠心病老年心律失常患者的疗效和安全性。
方法
两名研究人员将检索9个电子数据库（PubMed、Medline、Embase、Cochrane图书馆、科学网、中国知网、中文维普资讯、万方数据库和中国生物医学数据库），以识别所有符合纳入标准且在2018年10月之前发表的研究。文献筛选过程将按照PRISMA指南进行报告。在信息提取和方法学质量评估后，我们将使用Stata 12.0软件（STATA公司，德克萨斯州大学城）进行数据合成。主要结局将包括治疗有效率以及心电图或24小时动态心电图结果的改善情况，次要结局将包括相关血清学指标的改善、心功能分级和不良事件。
结果
数据合成结果将客观地说明参松养心胶囊治疗冠心病老年心律失常患者的疗效和安全性。
结论
研究结果将为参松养心胶囊治疗冠心病老年心律失常患者的应用提供参考。
注册信息
PROSPERO CRD42018112570
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