Sha Y C, Yu J X
Zhonghua Fu Chan Ke Za Zhi. 1989 Nov;24(6):354-6, 382.
From Jan. 1979 to Nov. 1987, 38 patients with invasive mole and 5 patients of choriocarcinoma were primarily treated with methotrexate and citrovorum factor (MTX-CF) rescue. Thirty-two patients had non-metastatic disease (stage I) and 11 had metastatic disease (stage IIA in 5 cases, stage IIB in 3 cases and stage IIIA in 3 cases). Complete remission was achieved in 28 (87.5%) of 32 patients with non-metastatic disease and in 9 (81.8%) of 11 patients with metastatic disease. Six patients with MTX-CF resistant tumors subsequently achieved complete remission with intravenous infusion of KSM and/or AT 1258. All patients were followed up periodically, 22 of them have been followed up for over 2 years, the longest duration of follow-up being 7 years. Seven of the 14 patients with preserved uterus became pregnant after recovery. All children grew up normally.
1979年1月至1987年11月，38例侵袭性葡萄胎患者和5例绒毛膜癌患者主要采用甲氨蝶呤及亚叶酸钙（MTX - CF）解救方案进行治疗。32例患者为无转移疾病（Ⅰ期），11例有转移疾病（5例为ⅡA期，3例为ⅡB期，3例为ⅢA期）。32例无转移疾病的患者中有28例（87.5%）实现完全缓解，11例有转移疾病的患者中有9例（81.8%）实现完全缓解。6例对MTX - CF耐药的肿瘤患者随后通过静脉输注更生霉素和/或AT 1258实现了完全缓解。所有患者均定期随访，其中22例随访超过2年，最长随访时间为7年。14例保留子宫的患者中有7例康复后怀孕。所有孩子均正常成长。
