Yang X, Yang N, Song H
Peking Union Medical College Hospital, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1996 Apr;31(4):199-202.
In order to save the life of the patients with drug-resistant choriocarcinoma due to improper treatment, selective arterial catheterization was used.
All the 71 cases were treated with systemic chemotherapy together with pelvic selective arterial chemotherapy. 5 of them had arterial chemotherapy plus arterial embolization for hemorrhage. In 13 patients who had lung metastasis, intraarterial injection of methotrexate (MTX) through bronchial arterial was added.
55 of 71 (77.8%) achieved complete remission and 10 (14.1%) had partial remission. One patient failed to follow-up. 5 died of various causes during hospitalization. On Follow-up 12 had survived for more than 5 years with no signs of recurrence. 2 of them had childbirth after recovery.
Systemic intravenous infusion chemotherapy in combination with arterial chemotherapy is useful for drug-resistant choriocarcinoma. In patients with intraperitoneal hemorrhage caused by tumor rupture, selective arterial embolization should be used as emergency treatment to effectively control the bleeding, in order that patients will have a chance for further chemotherapy.
为挽救因治疗不当而患耐药性绒毛膜癌患者的生命，采用了选择性动脉插管术。
71例患者均接受全身化疗及盆腔选择性动脉化疗。其中5例因出血接受动脉化疗加动脉栓塞术。13例发生肺转移的患者，加用经支气管动脉内注射甲氨蝶呤（MTX）。
71例中55例（77.8%）完全缓解，10例（14.1%）部分缓解。1例失访。5例在住院期间因各种原因死亡。随访时12例存活超过5年，无复发迹象。其中2例康复后生育。
全身静脉输注化疗联合动脉化疗对耐药性绒毛膜癌有效。对于肿瘤破裂引起腹腔内出血的患者，应采用选择性动脉栓塞术作为紧急治疗措施，以有效控制出血，使患者有机会接受进一步化疗。
