2011年对接触丙烯腈的化工厂工人死亡率的随访
Mortality among chemical plant workers exposed to acrylonitrile: 2011 follow-up.
作者信息
Marsh Gary M, Zimmerman Sarah D
机构信息
From the Center for Occupational Biostatistics and Epidemiology (Dr Marsh and Ms Zimmerman), Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pa.
出版信息
J Occup Environ Med. 2015 Feb;57(2):134-45. doi: 10.1097/JOM.0000000000000369.
OBJECTIVES
To update a cohort study of chemical workers and reevaluate lung cancer mortality in relation to acrylonitrile (AN) exposure.
METHODS
Subjects were 2096 workers employed during 1955 to 2011. We identified 474 deaths through 2011, and quantitatively estimated worker exposures to AN. Analyses included national and county-based standardized mortality ratios and relative risk regression of internal cohort rates.
RESULTS
We found no statistically significant excess mortality risks associated with Lima employment for any cause of death category, including lung cancer and other cancer sites implicated in previous studies.
CONCLUSIONS
This update provides no evidence that exposure to AN at levels experienced by Lima workers is associated with an increased risk of lung cancer mortality, as suggested in original study. Earlier reported bladder cancer risks decreased to a much lower, not statistically significant level.
目的
更新一项化工工人队列研究，并重新评估与丙烯腈（AN）暴露相关的肺癌死亡率。
方法
研究对象为1955年至2011年期间受雇的2096名工人。截至2011年，我们确认了474例死亡病例，并对工人接触AN的情况进行了定量评估。分析包括基于全国和各县的标准化死亡比以及内部队列率的相对风险回归。
结果
我们发现，在任何死因类别中，包括肺癌以及先前研究中涉及的其他癌症部位，利马就业与统计学上显著的超额死亡风险均无关联。
结论
此次更新未提供证据表明，利马工人所经历的AN暴露水平与肺癌死亡率增加有关，这与原研究的结论相反。早期报告的膀胱癌风险降至低得多的水平，且无统计学意义。
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