纤维生产中接触丙烯腈的工人死亡率：最新情况
Mortality among workers exposed to acrylonitrile in fiber production: an update.
作者信息
Symons J Morel, Kreckmann Kim H, Sakr Carine J, Kaplan A Michael, Leonard Robin C
机构信息
Epidemiology Program, DuPont Haskell Global Centers for Health and Environmental Sciences, EI du Pont de Nemours and Company, Newark, Delaware 19714, USA.
出版信息
J Occup Environ Med. 2008 May;50(5):550-60. doi: 10.1097/JOM.0b013e318162f640.
OBJECTIVE
The investigation updates the mortality experience through 2002 for a cohort of workers exposed to acrylonitrile (AN).
METHODS
Standardized mortality ratios (SMR) were estimated based on two reference populations: the US population and a regional employee population. Exposure-response analyses were conducted using Cox regression models for cumulative and mean intensity exposure measures.
RESULTS
In the cohort of 2548 workers, 839 deaths have occurred with 91 deaths due to respiratory system cancer. Most standardized mortality ratio estimates are at or near no-effects levels. Hazard ratio (HR) estimates indicate no increased mortality risk for respiratory system cancer (adjusted HR = 0.96, 95% confidence interval: 0.74, 1.25).
CONCLUSIONS
In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up.
目的
本调查更新了一组接触丙烯腈（AN）的工人截至2002年的死亡情况。
方法
基于两个参考人群估计标准化死亡比（SMR）：美国人群和区域雇员人群。使用Cox回归模型对累积和平均强度暴露测量进行暴露-反应分析。
结果
在2548名工人队列中，已发生839例死亡，其中91例死于呼吸系统癌症。大多数标准化死亡比估计值处于或接近无效应水平。风险比（HR）估计表明呼吸系统癌症的死亡风险没有增加（调整后HR = 0.96，95%置信区间：0.74，1.25）。
结论
总之，在超过五十年的随访中，纤维生产工人中，先验关注的主要死亡结局即呼吸系统癌症，与丙烯腈暴露增加无关。
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