更新后的 NCI/NIOSH 丙烯腈队列研究中对部分死亡率风险的再评估。
A reevaluation of selected mortality risks in the updated NCI/NIOSH acrylonitrile cohort study.
机构信息
Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
出版信息
Front Public Health. 2023 Apr 6;11:1122346. doi: 10.3389/fpubh.2023.1122346. eCollection 2023.
OBJECTIVES
The study aimed to determine whether the National Cancer Institute's (NCI) recent suggestion of associations between acrylonitrile (AN) exposure and mortality in lung and bladder cancer and pneumonitis is robust to alternative methods of data analysis.
MATERIALS AND METHODS
We used the Richardson method to indirectly adjust risk ratios (RRs) in relation to AN exposure for potential confounding by smoking and asbestos. We repeated key analyses omitting workers from Plant 4 to account for possible local, historical shipyard-related asbestos exposures.
RESULTS
The adjustment of lung cancer RRs for confounding by both smoking and asbestos and omitting Plant 4 workers yielded mostly decreased RRs and much less evidence of a positive association with cumulative AN exposure.
CONCLUSION
Overall, our reanalysis provided little evidence to support NCI's suggestion of associations between AN exposure and mortality in lung and bladder cancer and pneumonitis.
目的
本研究旨在确定美国国家癌症研究所（NCI）最近提出的丙烯腈（AN）暴露与肺癌、膀胱癌和肺炎死亡率之间存在关联的说法，是否能通过对数据的其他分析方法来验证。
材料与方法
我们使用 Richardson 法间接调整与 AN 暴露相关的风险比（RR），以纠正吸烟和石棉潜在的混杂因素。我们重复了关键分析，排除了来自 4 号工厂的工人，以考虑可能存在的局部、历史上与造船厂相关的石棉暴露。
结果
对肺癌 RR 进行的吸烟和石棉混杂因素调整，以及排除 4 号工厂工人的分析，结果大多是 RR 降低，并且与累积 AN 暴露呈正相关的证据大大减少。
结论
总的来说，我们的重新分析几乎没有提供证据来支持 NCI 提出的 AN 暴露与肺癌、膀胱癌和肺炎死亡率之间存在关联的说法。
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