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[应用单克隆抗体对结直肠癌转移灶进行免疫闪烁显像诊断]

[The immunoscintigraphic diagnosis of the metastases of colorectal cancer by using monoclonal antibodies].

作者信息

Peking A, Marinov V

出版信息

Khirurgiia (Sofiia). 1989;42(6):19-23.

PMID:2561374
Abstract

Sixty-four patients operated for colorectal cancer comprise the study group. CEA and CA-19.9 markers were used. The antibodies were labelled with 131I, using for the scintigraphy 99mTc as well. Eighty eight metastatic foci were detected, 67 of them (76.1 per cent) confirmed by the surgeon: Of 55 pelvic localizations, surgically detected were 47 (85.5 per cent), of 24 in the abdominal cavity 15 (62.5 per cent) were confirmed and of 9 in the liver--only 5 (55 per cent). Radioimmunoassay more accurate in pelvic localizations, whereas echography and computer tomography were more precise in liver examination (83.3 per cent).

摘要

研究组由64例接受结直肠癌手术的患者组成。使用癌胚抗原(CEA)和糖类抗原19.9(CA - 19.9)标志物。抗体用131I标记,同时使用99mTc进行闪烁扫描。共检测到88个转移灶,其中67个(76.1%)经外科医生确认:在55个盆腔定位中,手术检测到47个(85.5%),在24个腹腔定位中,15个(62.5%)得到确认,而在肝脏的9个定位中,仅5个(55%)得到确认。放射免疫测定在盆腔定位中更准确,而超声检查和计算机断层扫描在肝脏检查中更精确(83.3%)。

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