Fernandes Andréia K, Ziegler Bruna, Konzen Glauco L, Sanches Paulo R S, Müller André F, Pereira Rosemary P, Dalcin Paulo de Tarso R
Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.
Programa de Pós-Graduação em Ciências Pneumológicas, UFRGS, Brazil.
Open Respir Med J. 2014 Dec 26;8:41-7. doi: 10.2174/1874306401408010041. eCollection 2014.
Study the repeatability of the evaluation of the perception of dyspnea using an inspiratory resistive loading system in healthy subjects.
We designed a cross sectional study conducted in individuals aged 18 years and older. Perception of dyspnea was assessed using an inspiratory resistive load system. Dyspnea was assessed during ventilation at rest and at increasing resistive loads (0.6, 6.7, 15, 25, 46.7, 67, 78 and returning to 0.6 cm H2O/L/s). After breathing in at each level of resistive load for two minutes, the subject rated the dyspnea using the Borg scale. Subjects were tested twice (intervals from 2 to 7 days).
Testing included 16 Caucasian individuals (8 male and 8 female, mean age: 36 years). The median scores for dyspnea rating in the first test were 0 at resting ventilation and 0, 2, 3, 4, 5, 7, 7 and 1 point, respectively, with increasing loads. The median scores in the second test were 0 at resting and 0, 0, 2, 2, 3, 4, 4 and 0.5 points, respectively. The intra-class correlation coefficient was 0.57, 0.80, 0.74, 0.80, 0.83, 0.86, 0.91, and 0.92 for each resistive load, respectively. In a generalized linear model analysis, there was a statistically significant difference between the levels of resistive loads (p<0.001) and between tests (p=0.003). Dyspnea scores were significantly lower in the second test.
The agreement between the two tests of the perception of dyspnea was only moderate and dyspnea scores were lower in the second test. These findings suggest a learning effect or an effect that could be at least partly attributed to desensitization of dyspnea sensation in the brain.
研究在健康受试者中使用吸气阻力负荷系统评估呼吸困难感知的可重复性。
我们设计了一项针对18岁及以上个体的横断面研究。使用吸气阻力负荷系统评估呼吸困难感知。在静息通气和逐渐增加阻力负荷（0.6、6.7、15、25、46.7、67、78并回到0.6厘米水柱/升/秒）期间评估呼吸困难。在每个阻力负荷水平吸入两分钟后，受试者使用Borg量表对呼吸困难进行评分。受试者进行了两次测试（间隔2至7天）。
测试包括16名白种人个体（8名男性和8名女性，平均年龄：36岁）。第一次测试中呼吸困难评分的中位数在静息通气时为0分，随着负荷增加分别为0、2、3、4、5、7、7和1分。第二次测试中的中位数分数在静息时为0分，分别为0、0、2、2、3、4、4和0.5分。每个阻力负荷的组内相关系数分别为0.57、0.80、0.74、0.80、0.83、0.86、0.91和0.92。在广义线性模型分析中，阻力负荷水平之间（p<0.001）和测试之间（p=0.003）存在统计学上的显著差异。第二次测试中的呼吸困难评分显著更低。
两次呼吸困难感知测试之间的一致性仅为中等，且第二次测试中的呼吸困难评分更低。这些发现表明存在学习效应或至少部分可归因于大脑中呼吸困难感觉脱敏的效应。
