Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2022 Aug 26;17:1963-1973. doi: 10.2147/COPD.S367213. eCollection 2022.
This study aimed to assess the consistency of hand-held electronic incremental threshold loading device (I-TLD) and traditional constant threshold loading device (C-TLD) in measuring the perception of dyspnea (POD) in humans.
Thirty-eight patients with stable chronic obstructive pulmonary disease (COPD) and 41 non-COPD subjects were recruited for the study, all of whom were subjected to an external loading breathing test by gradually increasing the inspiratory load starting from 0 to 5, 10, 20, and 30 cmHO oral pressure using I-TLD and C-TLD. The Borg score measurement was performed immediately after the loading breath of each level. The linear regression slope a of Borg scores vs percentage of oral pressure from the patients' maximum represented patients' POD. The consistency of POD measured by the two devices was analyzed by two Related Samples Wilcoxon test, Spearman correlation analysis, and Bland-Altman analysis.
There was no significant difference in slope a measured by the two devices in all subjects. The Spearman correlation analysis revealed that the slope a measured by the two devices in the inspiratory loading breath test had a significant correlation: in COPD patients, = 0.678, ( < 0.001) and in non-COPD subjects, = 0.603, ( < 0.001). For the results of the Bland-Altman analysis of the whole subjects, 3.8% (3/79) points were outside of the 95% LoA confidence interval (CI) (-10.380, 9.457), and the LoA CI was acceptable, which depicted that the two devices were consistent in their estimation.
I-TLD was consistent with C-TLD in measuring POD in COPD patients and non-COPD subjects. I-TLD may be used as an alternative method to replace C-TLD to measure POD in COPD patients and non-COPD subjects.
本研究旨在评估手持式电子增量阈加载装置（I-TLD）与传统恒阈加载装置（C-TLD）在测量人体呼吸困难感知（POD）方面的一致性。
本研究纳入 38 例稳定期慢性阻塞性肺疾病（COPD）患者和 41 例非 COPD 患者，所有患者均接受外部加载呼吸测试，通过 I-TLD 和 C-TLD 逐渐增加吸气负荷，起始压力为 0 至 5、10、20 和 30 cmHO 口腔压力。在每个水平的加载呼吸后立即进行 Borg 评分测量。Borg 评分与患者最大口腔压力百分比的线性回归斜率 a 代表患者的 POD。采用两相关样本 Wilcoxon 检验、Spearman 相关分析和 Bland-Altman 分析对两种设备测量的 POD 一致性进行分析。
两种设备测量的斜率 a 在所有受试者中均无显著差异。Spearman 相关分析显示，两种设备在吸气加载呼吸试验中测量的斜率 a 具有显著相关性：在 COPD 患者中，r=0.678，（<0.001），在非 COPD 患者中，r=0.603，（<0.001）。对于所有受试者的 Bland-Altman 分析结果，3.8%（3/79）点超出 95%置信区间（CI）（-10.380，9.457），CI 范围可接受，表明两种设备在估计方面具有一致性。
I-TLD 与 C-TLD 在 COPD 患者和非 COPD 患者中测量 POD 方面具有一致性。I-TLD 可能作为一种替代方法，用于 COPD 患者和非 COPD 患者的 POD 测量。
