De Deene Y, Skyt P S, Hil R, Booth J T
Department of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney NSW 2109, Australia. Institute of Medical Physics, Faculty of Science, University of Sydney, Sydney, Australia.
Phys Med Biol. 2015 Feb 21;60(4):1543-63. doi: 10.1088/0031-9155/60/4/1543. Epub 2015 Jan 23.
Three dimensional radiation dosimetry has received growing interest with the implementation of highly conformal radiotherapy treatments. The radiotherapy community faces new challenges with the commissioning of image guided and image gated radiotherapy treatments (IGRT) and deformable image registration software.A new three dimensional anthropomorphically shaped flexible dosimeter, further called 'FlexyDos3D', has been constructed and a new fast optical scanning method has been implemented that enables scanning of irregular shaped dosimeters. The FlexyDos3D phantom can be actuated and deformed during the actual treatment. FlexyDos3D offers the additional advantage that it is easy to fabricate, is non-toxic and can be molded in an arbitrary shape with high geometrical precision.The dosimeter formulation has been optimized in terms of dose sensitivity. The influence of the casting material and oxygen concentration has also been investigated. The radiophysical properties of this new dosimeter are discussed including stability, spatial integrity, temperature dependence of the dosimeter during radiation, readout and storage, dose rate dependence and tissue equivalence.
随着高度适形放射治疗的实施,三维辐射剂量学受到了越来越多的关注。放射治疗界在图像引导和图像门控放射治疗(IGRT)以及可变形图像配准软件的调试方面面临新的挑战。一种新的三维人体形状的柔性剂量计,进一步称为“FlexyDos3D”,已经被构建出来,并且实施了一种新的快速光学扫描方法,该方法能够扫描不规则形状的剂量计。FlexyDos3D体模在实际治疗过程中可以被驱动和变形。FlexyDos3D具有易于制造、无毒且能以高几何精度模制成任意形状的额外优点。剂量计配方在剂量敏感性方面已经得到优化。还研究了铸造材料和氧气浓度的影响。讨论了这种新剂量计的放射物理性质,包括稳定性、空间完整性、辐射期间剂量计的温度依赖性、读出和储存、剂量率依赖性以及组织等效性。