Gengenbacher Martin, Dick Thomas
Tuberculosis Research Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117545, Republic of Singapore.
Antibacterial Drug Discovery Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117545, Republic of Singapore.
Chem Biol. 2015 Jan 22;22(1):5-6. doi: 10.1016/j.chembiol.2014.12.005.
Antibacterial drug discovery needs to develop new strategies to identify attractive hit-target couples for more effective lead finding and optimization. In this issue of Chemistry & Biology, Park and coworkers describe a novel target-based whole cell combination screening approach resulting in the identification of new inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.
抗菌药物研发需要制定新策略，以识别有吸引力的命中靶点组合，从而更有效地发现和优化先导化合物。在本期《化学生物学》中，帕克及其同事描述了一种基于靶点的新型全细胞组合筛选方法，该方法鉴定出了结核分枝杆菌生物素生物合成的新抑制剂。
