College of Pharmacy, The University of Texas at Austin, San Antonio, TX, United States.
Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States.
Front Cell Infect Microbiol. 2021 May 17;11:684515. doi: 10.3389/fcimb.2021.684515. eCollection 2021.
Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative to traditional drug discovery processes involving synthesis. Drugs that are currently approved or under development for non-antibiotic indications may possess antibiotic properties, and therefore may have repurposing potential, either alone or in combination with an antibiotic. They might also serve as "antibiotic adjuvants" to enhance the activity of certain antibiotics.
药物重定位，或为现有药物寻找新用途，已成为替代传统药物发现过程（涉及合成）的一种方法。目前批准或正在开发用于非抗生素适应症的药物可能具有抗生素特性，因此可能具有单独或与抗生素联合使用的重定位潜力。它们也可以作为“抗生素佐剂”，增强某些抗生素的活性。
