Naghibi Seyede Maryam, Ramezani Mohamad, Ayati Narjess, Zakavi Seyed Rasoul
Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Daru. 2015 Jan 24;23(1):5. doi: 10.1186/s40199-015-0094-9.
Carum carvi is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of Carum carvi. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the Carum carvi. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.
葛缕子是一种广泛可得的草药，多年来一直被用作食品添加剂和传统医学中的药物。其潜在的生物学效应包括镇痛、抗炎、抗焦虑和抗痉挛活性。我们报告了一名甲状腺乳头状癌患者，该患者正在接受左甲状腺素治疗，因摄入葛缕子而出现促甲状腺激素（TSH）水平升高。在左甲状腺素剂量不变的情况下，TSH水平升至60.3 mIU/L，停用葛缕子后降至正常范围。观察到摄入葛缕子后TSH水平出现如此显著变化，于是制作了葛缕子胶囊，一名研究人员以40 mg/kg/天的剂量在自己身上试用了这种药物。她有甲状腺功能减退病史，正在服用100 μg/天的左甲状腺素。摄入葛缕子2周后TSH显著升高，停用5个月后恢复到正常范围。本病例报告显示了食用葛缕子对接受左甲状腺素治疗的甲状腺功能减退患者TSH水平升高的影响。葛缕子的确切作用机制尚不清楚。
