Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, P.O. Box 37185/364, Qom, Iran.
Pharm Biol. 2011 Jul;49(7):679-86. doi: 10.3109/13880209.2010.539618. Epub 2011 Apr 26.
Carum carvi L., (Umbelliferae) known as caraway, is a famous traditional herbal plant supposed to contain active components with pharmacological properties.
In this study, the effects of caraway extracts on preventing sepsis induced by oxidative tissue injuries have been investigated by measuring heart and kidney oxidative stress parameters.
Sepsis was induced in rats (n = 6) by experimental cecal ligation and puncture (CLP) model. Then, either hydroalcoholic extract or essential oils (50 and 100 mg/kg body weight) were injected intraperitonially immediately after CLP operation. Twenty-four hours after CLP, the rats were anesthetized when kidney and heart tissues were removed to analyze the tissue oxidative stress parameters, that is, glutathione (GSH) and lipid peroxidation (LP).
Sepsis induction caused a significant increase in kidney but not heart LP, indicating that kidney was more affected by sepsis induction than heart. Kidney LP and plasma urea/creatinine ratio levels were readily reversed in rats treated with essential oils but not in those treated with hydroalcoholic extract. Unlike LP, the heart and kidney GSH levels were not affected in all treated groups.
Our data imply that caraway oils probably have a protective role in kidney tissue against oxidative injury in advanced stages of sepsis.
Carum carvi L.（伞形科），俗称香菜，是一种著名的传统草本植物，据称含有具有药理作用的活性成分。
本研究通过测量心脏和肾脏的氧化应激参数，研究了香菜提取物对预防氧化组织损伤引起的败血症的作用。
通过实验性盲肠结扎和穿刺（CLP）模型在大鼠中诱导败血症（n = 6）。然后，在 CLP 手术后立即腹膜内注射水醇提取物或精油（50 和 100 mg/kg 体重）。CLP 后 24 小时，当取出肾脏和心脏组织以分析组织氧化应激参数（即谷胱甘肽（GSH）和脂质过氧化（LP））时，对大鼠进行麻醉。
败血症诱导导致肾脏而不是心脏 LP 显著增加，表明肾脏比心脏更容易受到败血症诱导的影响。用精油治疗的大鼠的肾脏 LP 和血浆尿素/肌酐比水平迅速逆转，但用水醇提取物治疗的大鼠则没有。与 LP 不同，心脏和肾脏的 GSH 水平在所有治疗组中均不受影响。
我们的数据表明，在败血症的晚期，香菜油可能对肾脏组织的氧化损伤具有保护作用。
