Skrinjar Ivana, Vucicevic Boras Vanja, Bakale Iva, Andabak Rogulj Ana, Brailo Vlaho, Vidovic Juras Danica, Alajbeg Ivan, Vrdoljak Danko Velimir
Clinical Hospital Center Zagreb, Department of Oral Medicine, Gunduliceva 5, 10000, Zagreb, Croatia,
Clin Oral Investig. 2015 Apr;19(3):753-7. doi: 10.1007/s00784-015-1405-8. Epub 2015 Jan 25.
The aim of the present study was to compare the efficiency of oral spray based on thermal spring water (Buccotherm®) versus commercial saliva substitute (Xeros®) and marshmallow root on the quality of life in patients with hyposalivation.
A total of 60 patients with unstimulated salivary flow rate <0.2 ml/min were randomized into three groups. In the first group, 30 patients were using Buccotherm®; in the second group, 15 patients were using Xeros®; and in the third group, 15 patients were using marshmallow root. Therapy lasted for 2 weeks; everyday, patients used one of the products four times a day. Quality of life was measured by the Croatian version of Oral Health Impact Profile 14 questionnaire, and visual analog scale was used to determine the intensity of dry mouth before and after therapy. Statistical analysis was performed by Wilcoxon signed-rank test and Kruskal-Wallis test. Standardized effect size was calculated for OHIP following treatment.
Buccotherm® has shown the biggest effect on quality of life in patients with hyposalivation. Intensity of dry mouth was lower after the applied therapy whatever substitute patients used.
We recommend the use of all three saliva substitutes for decreasing the intensity of dry mouth symptoms as well as improvement in the quality of life.
Although all tested agents showed beneficial effect in alleviating hyposalivation symptoms, it seems that Buccotherm® was superior to Xeros® and marshmallow root.
本研究旨在比较基于温泉水的口腔喷雾剂（Buccotherm®）与商用唾液替代品（Xeros®）以及药蜀葵根对唾液分泌减少患者生活质量的影响。
总共60例非刺激性唾液流速<0.2 ml/分钟的患者被随机分为三组。第一组，30例患者使用Buccotherm®；第二组，15例患者使用Xeros®；第三组，15例患者使用药蜀葵根。治疗持续2周；患者每天使用其中一种产品4次。生活质量通过克罗地亚版口腔健康影响量表14问卷进行测量，视觉模拟量表用于确定治疗前后口干的强度。采用Wilcoxon符号秩检验和Kruskal-Wallis检验进行统计分析。治疗后计算OHIP的标准化效应量。
Buccotherm®对唾液分泌减少患者的生活质量显示出最大的影响。无论患者使用何种替代品，治疗后口干强度均降低。
我们建议使用所有三种唾液替代品来减轻口干症状的强度并改善生活质量。
尽管所有测试药物在缓解唾液分泌减少症状方面均显示出有益效果，但Buccotherm®似乎优于Xeros®和药蜀葵根。
