Aframian Doron J, Mizrahi Boaz, Granot Igal, Domb Abraham J
Department of Oral Medicine, Hadassah Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel.
Quintessence Int. 2010 Mar;41(3):e36-42.
Salivary gland impairment is a major problem that can result in hyposalivation and a decrease in quality of life. Causes for mouth dryness can be grossly classified into three major groups: iatrogenic, immunogenic, and metabolic. At present, insufficient therapies exist to ease morbidity in this growing number of affected individuals. A need for new products to relieve oral dryness is mandatory. The aim of this study was to evaluate a mucoadhesive lipid-based bioerodable tablet as a novel device to decrease signs and symptoms associated with mouth dryness.
Twenty xerostomic patients were divided into two groups. In group 1, the mucoadhesive tablet was applied to the hard palate, while in group 2, Biotène mouthwash was applied and served as a control. Sialometry measurements, as well as a questionnaire assessing mouth dryness, were obtained before and after treatment.
Application of the mucoadhesive tablets resulted in a significant reduction in the sensation of the mouth dryness (P = .016) compared to Biotène. Moreover, a 1.5-fold increase in unstimulated whole saliva flow was obtained after 30 minutes in the treatment group.
A lipid-based mucoadhesive tablet has a beneficial role in reducing the sensation of dryness in patients with xerostomia.
唾液腺损伤是一个主要问题，可导致唾液分泌减少和生活质量下降。口干的原因大致可分为三大类：医源性、免疫源性和代谢性。目前，对于越来越多受影响个体的发病率，现有的治疗方法并不充分。迫切需要新产品来缓解口腔干燥。本研究的目的是评估一种基于脂质的粘膜粘附性生物可蚀性片剂作为一种新型装置，以减少与口干相关的体征和症状。
20名口干患者被分为两组。在第1组中，将粘膜粘附片剂应用于硬腭，而在第2组中，应用比奥泉漱口水作为对照。在治疗前后进行唾液流量测量以及评估口干的问卷调查。
与比奥泉相比，粘膜粘附片剂的应用导致口干感觉显著降低（P = 0.016）。此外，治疗组在30分钟后未刺激的全唾液流量增加了1.5倍。
基于脂质的粘膜粘附片剂在减轻口干患者的干燥感觉方面具有有益作用。
