氟虫腈与氯菊酯新组合对蓖麻硬蜱和血红扇头蜱的杀蜱效果
Acaricidal efficacy of a new combination of fipronil and permethrin against Ixodes ricinus and Rhipicephalus sanguineus ticks.
作者信息
Dumont Pascal, Chester Theodore S, Gale Boyd, Soll Mark, Fourie Josephus J, Beugnet Frédéric
机构信息
Merial S.A.S., 29 Av. Tony Garnier, 69007, Lyon, France.
Merial Limited, 3239 Satellite Blvd., Duluth, GA, 30096, USA.
出版信息
Parasit Vectors. 2015 Jan 27;8:51. doi: 10.1186/s13071-015-0681-0.
BACKGROUND
Two blinded, controlled laboratory studies were conducted to assess the acaricidal efficacy of a new combination of fipronil and permethrin (Frontline Tri-Act/Frontect) against two tick species. Study A evaluated the efficacy of the product against both Ixodes ricinus and Rhipicephalus sanguineus and Study B evaluated the efficacy against R. sanguineus only.
METHODS
16 (Study A) and 12 (Study B) healthy adult dogs were allocated to two groups in each study. Dogs in Group 1 served as untreated controls. Dogs in Group 2 were treated with a new topical spot-on formulation containing 6.76% (w/v) fipronil + 50.48% (w/v) permethrin once on Day 0. Each dog of study A was infested with 50 unfed adult ticks of each species and each dog of study B was infested with 50 unfed adult Rhipicephalus sanguineus prior to treatment (Day -2 in Study A, Day -1 in Study B) and post treatment on Days 7, 14, 21 and 28. The ticks were removed and counted 48 h after treatment (Day 2) or subsequent infestations (Days 9, 16, 23 and 30). Acaricidal efficacy was defined as the percent reduction in the number of live ticks in the treated group compared to the untreated control group.
RESULTS
The percent efficacy in the treated group for R. sanguineus was 100%, 100%, 100%, 100% and 96.7% in Study A, and 94.4%, 100%, 100%, 98.7% and 98.0% in Study B, for counts performed on Days 2, 9, 16, 23 and 30, respectively. For I. ricinus, in Study A, the percent efficacy of the treatment was 100%, 100%, 100%, 100% and 99.2% for counts performed on Days 2, 9, 16, 23 and 30, respectively. There was a significant difference of the geometric mean numbers of live ticks between the treated and control groups at each time point in each study (p = 0.005 for every day in Study A, and p < 0.005 for every day in Study B).
CONCLUSIONS
A single topical administration of a combination of fipronil and permethrin provides excellent acaricidal efficacy against both I. ricinus and R. sanguineus for at least 4 weeks.
背景
进行了两项双盲对照实验室研究，以评估氟虫腈和氯菊酯新组合（福来恩三效/福来恩特）对两种蜱虫的杀蜱效果。研究A评估了该产品对蓖麻硬蜱和血红扇头蜱的效果，研究B仅评估了对血红扇头蜱的效果。
方法
在每项研究中，16只（研究A）和12只（研究B）健康成年犬被分为两组。第1组的犬作为未治疗对照。第2组的犬在第0天用一种新的局部点滴剂配方进行治疗，该配方含有6.76%（w/v）氟虫腈+50.48%（w/v）氯菊酯。研究A的每只犬在治疗前（研究A的第-2天，研究B的第-1天）以及治疗后的第7、14、21和28天，感染50只每种未进食的成年蜱虫，研究B的每只犬感染50只未进食的成年血红扇头蜱。在治疗后48小时（第2天）或后续感染后（第9、16、23和30天）移除并计数蜱虫。杀蜱效果定义为治疗组存活蜱虫数量相对于未治疗对照组减少的百分比。
结果
在研究A中，治疗组对血红扇头蜱的有效率在第2、9、16、23和30天分别为100%、100%、100%、100%和96.7%；在研究B中，分别为94.4%、100%、100%、98.7%和98.0%。对于蓖麻硬蜱，在研究A中，治疗的有效率在第2、9、16、23和30天分别为100%、100%、100%、100%和99.2%。在每项研究的每个时间点，治疗组和对照组存活蜱虫的几何平均数存在显著差异（研究A中每天p = 0.005，研究B中每天p < 0.005）。
结论
单次局部施用氟虫腈和氯菊酯的组合对蓖麻硬蜱和血红扇头蜱均具有至少4周的优异杀蜱效果。
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