[采用健康评估问卷-残疾指数对90例系统性硬化症患者的生活质量进行评估与分析]

[Evaluations and analyses of quality of life in 90 patients with systemic sclerosis by health assessment questionnaire-disability index].

作者信息

Mao Xiaofei, Sun Qiuning

机构信息

Department of Dermatology, Peking Union Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Department of Dermatology, Peking Union Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Email:

出版信息

Zhonghua Yi Xue Za Zhi. 2014 Dec 2;94(44):3471-4.

PMID:25622735

Abstract

OBJECTIVE

To evaluate health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc) using health assessment questionnaire-disability index (HAQ-DI), visual analog scale (VAS) and scleroderma assessment questionnaire (SAQ).

METHODS

The questionnaires of HAQ-DI, VAS and SAQ were administered to 50 controls and 90 SSc patients from September to December 2013. And SSc patients were also evaluated for subset (limited & diffuse SSc), age, disease duration, autoantibodies and skin & internal organ involvement.

RESULTS

The physical summary scores of HAQ-DI in dressing, cleaning and hand functions domains were higher in SSc patients than those in controls (all P < 0.05). As for VAS, the specific clinical manifestations (Pain,0.60 (0.20-1.40); Raynaud's phenomenon, 9.00(4.00-11.00); finger ulcers, 1.00(0.00-5.00); gastrointestinal symptoms, 5.00(1.00-6.50); respiratory symptoms, 3.00(0.00-6.00)) of SSc patients impacted their HRQOL. SAQ showed higher scores in blood vascular, respiratory, digestive and musculoskeletal systems for SSc patients (1.00(0.75-1.50), 0.50(0.33-0.67), 0.40(0.20-0.80), 0.13(0.00-0.38) vs 0.00(0.00-0.00), all P < 0.05).

CONCLUSIONS

HRQOL is impaired in patients with SSc, especially in physical domains. And higher scores in SSc patients with specific organ involvement suggest that severe disease has worse HRQOL.

摘要

目的

使用健康评估问卷残疾指数（HAQ-DI）、视觉模拟量表（VAS）和硬皮病评估问卷（SAQ）评估系统性硬化症（SSc）患者的健康相关生活质量（HRQOL）。

方法

2013年9月至12月，对50名对照者和90名SSc患者进行了HAQ-DI、VAS和SAQ问卷调查。还对SSc患者的亚型（局限性和弥漫性SSc）、年龄、病程、自身抗体以及皮肤和内脏器官受累情况进行了评估。

结果

SSc患者在HAQ-DI的穿衣、清洁和手部功能领域的身体总结得分高于对照组（所有P<0.05）。对于VAS，SSc患者的特定临床表现（疼痛，0.60（0.20-1.40）；雷诺现象，9.00（4.00-1,100）；手指溃疡，1.00（0.00-5.00）；胃肠道症状，5.00（1.00-6.50）；呼吸道症状，3.00（0.00-6.00））影响了他们的HRQOL。SAQ显示SSc患者在血管、呼吸、消化和肌肉骨骼系统方面得分更高（1.00（0.75-1.50），0.50（0.33-0.67），0.40（0.20-0.80），0.l3（0.00-0.38）对0.00（0.00-0.00），所有P<0.05）。