Blois Sandra M, Conrad Melanie L, Freitag Nancy, Barrientos Gabriela
Universitätsmedizin Berlin, Charité-Center 12 Internal Medicine and Dermatology, Medizinische Klinik mit Schwerpunkt Psychosomatik, Reproductive Medicine Research Group, Berlin, Germany.
Universitätsmedizin Berlin, Charité-Center 12 Internal Medicine and Dermatology, Medizinische Klinik mit Schwerpunkt Psychosomatik, Reproductive Medicine Research Group, Berlin, Germany.
J Reprod Immunol. 2015 Apr;108:33-41. doi: 10.1016/j.jri.2014.12.001. Epub 2014 Dec 30.
Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been shown to augment signalling pathways that lead to endothelial cell activation, cell proliferation, migration and tube formation in vitro in addition to angiogenesis in vivo. Angiogenesis during gestation ensures not only proper foetal growth and development, but also maternal health. Consequently, restriction of placental blood flow has major consequences for both foetus and mother, leading to pregnancy diseases. In this review we summarise both the established and the emerging roles of galectin in angiogenesis and discuss the possible implications during healthy and pathological gestation.
半乳糖凝集素家族成员已被证明在生殖过程中发挥多种作用。它们有助于胎盘形成、母体免疫调节，并促进包括孕期蜕膜化和胎盘形成在内的血管生成。在新生血管形成方面，半乳糖凝集素已被证明除了在体内促进血管生成外，还能增强体外导致内皮细胞激活、细胞增殖、迁移和管状结构形成的信号通路。孕期血管生成不仅确保胎儿的正常生长发育，也关乎母体健康。因此，胎盘血流受限对胎儿和母亲都会产生重大影响，引发妊娠疾病。在本综述中，我们总结了半乳糖凝集素在血管生成中已明确的和新出现的作用，并讨论了其在正常和病理妊娠过程中的可能影响。
