Blois Sandra M, Verlohren Stefan, Wu Gang, Clark Gary, Dell Anne, Haslam Stuart M, Barrientos Gabriela
Experimental and Clinical Research Center, A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité-Universitätsmedizin Berlin, AG GlycoImmunology, Berlin, Germany.
Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Semin Immunopathol. 2020 Aug;42(4):469-486. doi: 10.1007/s00281-020-00801-4. Epub 2020 Jun 29.
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
越来越多的证据表明，半乳糖凝集素是一类在进化上保守的聚糖结合蛋白家族，在妊娠中发挥关键作用，包括胚泡着床、母胎免疫耐受、胎盘发育和母体血管扩张，从而为发育中的胎儿建立一个健康的环境。在这篇综述中，我们全面介绍了半乳糖凝集素在塑造健康妊娠特征性细胞回路中的作用。我们描述了目前对半乳糖凝集素在足月和早产中的认识，并讨论了半乳糖凝集素-聚糖回路如何促进维持母体耐受性和预防微生物感染的关键免疫途径。更深入地了解调节早产早期事件的糖免疫途径可能为治疗这种毁灭性综合征提供更广泛的转化潜力。
