Melato M, Valente M, Mucli E, Muuse M M, Taraglio S
Institute of Pathological Anatomy, University of Trieste, Ospedale Maggiore, Italy.
J Gastroenterol Hepatol. 1989 Nov-Dec;4(6):521-7. doi: 10.1111/j.1440-1746.1989.tb00856.x.
One hundred consecutive cases of hepatocellular carcinoma (HCC) in cirrhosis observed at autopsy were studied and their pathological aspects were compared with those reported in the literature. The results, which are representative of HCC epidemiology in a geographical area where cirrhosis is mostly due to alcohol abuse, show that similarities in the architectural pattern of HCC and weight of the liver exist between our material and samples with different aetiology and epidemiology. A relationship between the histological grade of HCC and its propensity to metastasize was demonstrated. The reported better prognosis of clear cells per se could not be confirmed, although clear cell HCC occurred exclusively in grade 2. It was also demonstrated that the relationship between grading and staging was strongly influenced by the association of HCC with cirrhosis, which is a fact that is usually overlooked by the common staging (and grading) methods.
对100例尸检发现的肝硬化合并肝细胞癌（HCC）连续病例进行了研究，并将其病理特征与文献报道的进行了比较。这些结果代表了在一个肝硬化主要由酒精滥用引起的地理区域内HCC的流行病学情况，表明我们的材料与具有不同病因和流行病学特征的样本之间，HCC的结构模式和肝脏重量存在相似性。研究证实了HCC的组织学分级与其转移倾向之间的关系。尽管透明细胞HCC仅发生在2级，但所报道的透明细胞本身预后较好这一点未能得到证实。还表明，分级与分期之间的关系受到HCC与肝硬化关联的强烈影响，而这一事实通常被常用的分期（和分级）方法所忽视。
