Yuan Zhenyun, Wang Mingwei, Yan Baoyong, Gu Ping, Jiang Xiangming, Yang Xiufen, Cui Dongsheng
First Hospital of Hebei Medical University, Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang 050031, Hebei Province, China.
Neural Regen Res. 2012 Aug 15;7(23):1797-804. doi: 10.3969/j.issn.1673-5374.2012.23.006.
In this study, we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated- resistant mouse 1 strain. Mice from each strain were housed in an enriched environment (including a platform, running wheels, tunnel, and some toys) or a standard environment for 3 months. The mice housed in the enriched environment exhibited shorter escape latencies and a greater percentage of time in the target quadrant in the Morris water maze test, and they exhibited reduced errors and longer latencies in step-down avoidance experiments compared with mice housed in the standard environment. Correspondently, brain-derived neurotrophic factor mRNA and protein expression in the hippocampus was significantly higher in mice housed in the enriched environment compared with those housed in the standard environment, and the level of hippocampal brain-derived neurotrophic factor protein was positively correlated with the learning and memory abilities of mice from the senescence-accelerated prone mouse 8 strain. These results suggest that an enriched environment improved cognitive performance in mice form the senescence-accelerated prone mouse 8 strain by increasing brain-derived neurotrophic factor expression in the hippocampus.
在本研究中，我们检测了来自衰老加速易感性小鼠8品系的3月龄雌性小鼠，以及来自衰老加速抗性小鼠1品系的年龄匹配的同源正常衰老雌性小鼠。每个品系的小鼠分别饲养在丰富环境（包括一个平台、跑轮、隧道和一些玩具）或标准环境中3个月。与饲养在标准环境中的小鼠相比，饲养在丰富环境中的小鼠在莫里斯水迷宫试验中表现出较短的逃避潜伏期和在目标象限中所占时间的百分比更高，并且在避暗实验中表现出错误减少和潜伏期延长。相应地，与饲养在标准环境中的小鼠相比，饲养在丰富环境中的小鼠海马中脑源性神经营养因子mRNA和蛋白表达显著更高，并且海马脑源性神经营养因子蛋白水平与衰老加速易感性小鼠8品系小鼠的学习和记忆能力呈正相关。这些结果表明，丰富环境通过增加海马中脑源性神经营养因子的表达来改善衰老加速易感性小鼠8品系小鼠的认知表现。
