Żmijewska-Tomczak Małgorzata, Milecki Piotr, Olek-Hrab Karolina, Hojan Katarzyna, Golusiński Wojciech, Rucińska Anna, Adamska Anna
Department of Radiotherapy, Greater Poland Cancer Center, Poznan, Poland.
Department of Radiotherapy, Greater Poland Cancer Center, Poznan, Poland ; Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland.
Arch Med Sci. 2014 Dec 22;10(6):1153-9. doi: 10.5114/aoms.2013.34317. Epub 2013 Apr 19.
Radiotherapy (RT) in combination with chemotherapy is a standard of care for patients with head and neck squamous cell carcinoma (HNSCC). The RT is associated with side effects, which impact on quality of life (QoL). Thus, the aim of this prospective longitudinal study was to investigate the impact of RT on the QoL of patients with HNSCC during RT.
From September 2008 to February 2010, 205 patients with locally advanced HNSCC were enrolled. The data pertaining to their QoL were collected using the EORTC QLQ-C30 and the EORTC Head and Neck Module (QLQ-H&N35) and then all items were transformed to a 0-100 scale according to the guidelines of the EORTC. The following clinical factors were chosen to study their potential influence on the QoL; site of primary, clinical stage, and methods of therapy: RT vs. chemoradiotherapy (CRT). Additionally, the sociodemographic factors (age, gender, education, habit of smoking) were studied.
Deterioration of almost all scales and items in the QLQ-C30 and QLQ-H&N35 questionnaire were noted at the end of RT. The following factors negatively influenced the QoL: age < 60 years (p < 0.05), female gender (p < 0.05), habit of smoking (p < 0.01), advanced clinical stage (III and IV) (p < 0.05), site of primary (larynx, hypopharynx) (p < 0.01), and CRT (p < 0.01).
Our study showed that RT significantly negatively influenced QoL at the end of the RT course. Additionally, this study demonstrated that age, gender, smoking habit, tumor site, and clinical stage of disease showed a significant effect on the QoL of HNSCC patients during RT.
放射治疗（RT）联合化疗是头颈部鳞状细胞癌（HNSCC）患者的标准治疗方案。放疗会产生副作用，影响生活质量（QoL）。因此，这项前瞻性纵向研究的目的是调查放疗对HNSCC患者放疗期间生活质量的影响。
2008年9月至2010年2月，招募了205例局部晚期HNSCC患者。使用欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）和欧洲癌症研究与治疗组织头颈部模块问卷（QLQ-H&N35）收集他们的生活质量数据，然后根据EORTC的指南将所有项目转换为0至100分的量表。选择以下临床因素来研究它们对生活质量的潜在影响：原发部位、临床分期和治疗方法（放疗与放化疗[CRT]）。此外，还研究了社会人口统计学因素（年龄、性别、教育程度、吸烟习惯）。
在放疗结束时，QLQ-C30和QLQ-H&N35问卷中几乎所有量表和项目都出现了恶化。以下因素对生活质量有负面影响：年龄<60岁（p<0.05）、女性（p<0.05）、吸烟习惯（p<0.01）、晚期临床分期（III期和IV期）（p<0.05）、原发部位（喉、下咽）（p<0.01）和放化疗（p<0.01）。
我们的研究表明，放疗疗程结束时，放疗对生活质量有显著的负面影响。此外，这项研究表明，年龄、性别、吸烟习惯、肿瘤部位和疾病临床分期对HNSCC患者放疗期间的生活质量有显著影响。
