Eison M S
CNS Biology, Bristol-Myers Squibb Company, Wallingford, CT 06492-7660.
J Clin Psychopharmacol. 1990 Jun;10(3 Suppl):26S-30S.
Anxiety and depression have traditionally been considered independent pathologies. Recent evidence suggests that these disorders may be related. Some tricyclic antidepressant drugs appear to be effective against generalized anxiety disorders in man, and in animal models, chronic administration of some anxiolytic drugs produces activities predictive of antidepressant potential. It is proposed that imbalances in serotonergic neurotransmission may contribute significantly to both pathologies and that agents that act as serotonin partial agonists may normalize neurotransmission in both serotonin deficit (depression) and excess (anxiety) diseases. The azapirones, a new class of drugs that includes buspirone, ipsapirone, and gepirone, act as serotonin partial agonists at the serotonergic type1A receptor, and may prove useful in treating multiple psychopathologies characterized by aberrant serotonin neurotransmission.
焦虑症和抑郁症传统上被认为是独立的病症。最近的证据表明，这些疾病可能有关联。一些三环类抗抑郁药似乎对人类的广泛性焦虑症有效，并且在动物模型中，长期服用某些抗焦虑药会产生具有抗抑郁潜力的活性。有人提出，血清素能神经传递失衡可能在这两种病症中都起重要作用，而作为血清素部分激动剂的药物可能会使血清素缺乏（抑郁症）和血清素过量（焦虑症）疾病中的神经传递恢复正常。氮杂螺环癸烷酮类药物是一类新药，包括丁螺环酮、伊沙匹隆和吉哌隆，它们在血清素能1A型受体上作为血清素部分激动剂起作用，可能在治疗以血清素神经传递异常为特征的多种精神病症方面有用。
