Moroşan George-Cătălin, Moroşan Andreea-Cătălina, Ionescu Cătălina, Sava Anca
Department of Morpho-Functional Sciences I, Grigore T. Popa University Medicine and Pharmacy, Iasi, Romania.
Discipline of Psychiatry, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.
Arch Clin Cases. 2024 Dec 20;11(4):120-126. doi: 10.22551/2024.45.1104.10302. eCollection 2024.
Brain tumors, despite the high mortality and morbidity, they are a rare type of heterogenous tumors that are highly dependent on sex, age, race, level of education, and socioeconomic status. Due to their high mortality rates, it is important to identify as many potential biomarkers for early detection as the earlier the tumor is discovered, the better the prognosis. One such early biomarker we propose in the current paper is the assessment of anxiety, depression, and cognitive changes. In most cancer patients, a certain degree of anxiety and depression is expected upon receiving the diagnosis as it triggers fears regarding the prognosis, possible side effects of the treatment, and even the possibility of the treatment failing. In this paper we analyzed the way anxiety, depression, and cognitive changes present themselves in the case of several types of tumors and whether these could be used as early markers. We have observed that most of the cognitive changes present are due to the location, size, and type of the tumor with some highly connected to anxiety and depression. Moreover, in the case of certain tumors, the removal of the mass has not improved the mood or cognitive function.
脑肿瘤尽管具有高死亡率和高发病率，但它们是一种罕见的异质性肿瘤，高度依赖于性别、年龄、种族、教育水平和社会经济地位。由于其高死亡率，识别尽可能多的早期检测潜在生物标志物非常重要，因为肿瘤发现得越早，预后越好。我们在本文中提出的一种这样的早期生物标志物是对焦虑、抑郁和认知变化的评估。在大多数癌症患者中，确诊后出现一定程度的焦虑和抑郁是可以预料的，因为这会引发对预后、治疗可能的副作用甚至治疗失败可能性的恐惧。在本文中，我们分析了焦虑、抑郁和认知变化在几种肿瘤病例中的表现方式，以及这些是否可以用作早期标志物。我们观察到，出现的大多数认知变化是由于肿瘤的位置、大小和类型，其中一些与焦虑和抑郁高度相关。此外，在某些肿瘤的情况下，切除肿块并没有改善情绪或认知功能。
