Stones Daniel H, Krachler Anne-Marie
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
Int J Mol Sci. 2015 Jan 23;16(2):2626-40. doi: 10.3390/ijms16022626.
The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.
细菌物种定殖并感染宿主生物体的能力严重依赖于它们黏附到宿主细胞表面的能力。已知黏附到细胞表面对于某些毒力因子的激活和传递至关重要，但也可直接影响宿主细胞信号传导，以帮助细菌传播和存活。在本综述中，我们将讨论细菌黏附领域的最新进展，我们如何开始阐明黏附素对宿主细胞信号传导的影响，以及这些变化如何在细菌的存活和逃避免疫反应方面帮助细菌。最后，我们将强调利用细菌黏附素如何可能为治疗多种细菌感染提供新的治疗途径。
