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在温和条件下通过激活仲酰胺直接区域选择性合成四唑盐。

Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions.

机构信息

University of Vienna , Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria.

University of Vienna , Insitute of Theoretical Chemistry, Währinger Strasse 17, 1090 Vienna, Austria.

出版信息

Org Lett. 2017 May 19;19(10):2662-2665. doi: 10.1021/acs.orglett.7b01004. Epub 2017 May 9.

DOI:10.1021/acs.orglett.7b01004
PMID:28485608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5442602/
Abstract

Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.

摘要

四唑盐是具有广泛应用的生物活性分子，在生化分析中有着广泛的应用。本文通过形式上的（3 + 2）环加成反应，描述了四唑盐的区域选择性合成。简单的酰胺和叠氮化物可以作为起始原料，反应条件温和，具有广泛的官能团耐受性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21cf/5442602/5a94dcd4e4a0/ol-2017-01004q_0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21cf/5442602/3992303bde86/ol-2017-01004q_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21cf/5442602/75a50e9cf423/ol-2017-01004q_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21cf/5442602/55a00e837887/ol-2017-01004q_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21cf/5442602/5a94dcd4e4a0/ol-2017-01004q_0002.jpg

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