计算机断层扫描灌注成像在神经内分泌性肝转移瘤及正常肝脏中采样间隔对灌注值的影响
Effect on perfusion values of sampling interval of computed tomographic perfusion acquisitions in neuroendocrine liver metastases and normal liver.
作者信息
Ng Chaan S, Hobbs Brian P, Wei Wei, Anderson Ella F, Herron Delise H, Yao James C, Chandler Adam G
机构信息
From the Departments of *Diagnostic Radiology, †Biostatistics, ‡Gastrointestinal Medical Oncology, and §Imaging Physics, The University of Texas, MD Anderson Cancer Center, Houston, TX; and ∥CT Research, GE Healthcare, Waukesha, WI.
出版信息
J Comput Assist Tomogr. 2015 May-Jun;39(3):373-82. doi: 10.1097/RCT.0000000000000212.
OBJECTIVE
This study aimed to assess the effects of sampling interval (SI) of computed tomographic (CT) perfusion acquisitions on CT perfusion values in normal liver and liver metastases from neuroendocrine tumors.
METHODS
Computed tomographic perfusion in 16 patients with neuroendocrine liver metastases was analyzed using distributed-parameter modeling to yield tissue blood flow, blood volume, mean transit time, permeability, and hepatic arterial fraction for tumor and normal liver. Computed tomographic perfusion values for the reference SI of 0.5 s (SI0.5) were compared with those of SI data sets of 1 second, 2 seconds, 3 seconds, and 4 seconds using mixed-effects model analyses.
RESULTS
Increases in SI beyond 1 second were associated with significant and increasing departures of CT perfusion parameters from the reference values at SI0.5 (P ≤ 0.0009). Computed tomographic perfusion values deviated from the reference with increasing uncertainty with increasing SIs. Findings for normal liver were concordant.
CONCLUSIONS
Increasing SIs beyond 1 second yield significantly different CT perfusion parameter values compared with the reference values at SI0.5.
目的
本研究旨在评估计算机断层扫描（CT）灌注采集的采样间隔（SI）对正常肝脏及神经内分泌肿瘤肝转移灶CT灌注值的影响。
方法
采用分布参数模型分析16例神经内分泌肝转移患者的CT灌注情况，以得出肿瘤及正常肝脏的组织血流量、血容量、平均通过时间、通透性和肝动脉分数。使用混合效应模型分析，将0.5秒（SI0.5）的参考采样间隔的CT灌注值与1秒、2秒、3秒和4秒的采样间隔数据集的灌注值进行比较。
结果
采样间隔超过1秒时，CT灌注参数与SI0.5时的参考值相比出现显著且不断增加的偏差（P≤0.0009）。随着采样间隔增加，CT灌注值与参考值的偏差及不确定性也增加。正常肝脏的结果与此一致。
结论
与SI0.5时的参考值相比，采样间隔超过1秒会产生显著不同的CT灌注参数值。
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