Soma Ryoko, Moriyama Muka, Ohno-Matsui Kyoko
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan,
Int Ophthalmol. 2015 Apr;35(2):261-8. doi: 10.1007/s10792-015-0042-1. Epub 2015 Jan 28.
The purpose of this study was to investigate the hemodynamics of focal choroidal excavations (FCEs). Four eyes of four patients with a FCE were studied. Indocyanine green angiography (ICGA), laser speckle flowgraphy (LSFG), optical coherence tomography (OCT), and multi-focal electroretinography (mfERG) were performed to investigate the choroidal hemodynamics and the morphological and functional changes. The mean depth of the FCE determined by OCT was 222.5 ± 49.5 μm with a range of 164-272 μm. In one case, subretinal fluid was observed in the excavation, and in three cases, subretinal fluid was not observed. ICGA showed hypofluorescence, and laser flowgraphy (LSFG) showed decreased choroidal blood flow at the excavation in all cases. Three cases were symptomatic, and the amplitudes of the mfERGs were reduced. FCEs cause a decrease of choroidal blood flow. In three of four cases, the mfERGs were depressed over the FCEs leading to symptoms.
本研究的目的是调查局限性脉络膜凹陷（FCEs）的血流动力学。对4例患有FCE的患者的4只眼睛进行了研究。进行了吲哚菁绿血管造影（ICGA）、激光散斑血流图（LSFG）、光学相干断层扫描（OCT）和多焦视网膜电图（mfERG），以研究脉络膜血流动力学以及形态和功能变化。经OCT测定，FCE的平均深度为222.5±49.5μm，范围为164 - 272μm。1例在凹陷处观察到视网膜下液，3例未观察到视网膜下液。ICGA显示低荧光，激光血流图（LSFG）显示所有病例中凹陷处脉络膜血流减少。3例有症状，mfERG的振幅降低。FCEs导致脉络膜血流减少。4例中的3例，FCEs上方的mfERG降低，导致出现症状。
