Rao Xiaoquan, Patel Priti, Puett Robin, Rajagopalan Sanjay
*Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park.
*Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park
Toxicol Sci. 2015 Feb;143(2):231-41. doi: 10.1093/toxsci/kfu250.
Recent studies in both humans and animals suggest that air pollution is an important risk factor for type 2 diabetes mellitus (T2DM). However, the mechanism by which air pollution mediates propensity to diabetes is not fully understood. While a number of epidemiologic studies have shown a positive association between ambient air pollution exposure and risk for T2DM, some studies have not found such a relationship. Experimental studies in susceptible disease models do support this association and suggest the involvement of tissues involved in the pathogenesis of T2DM such as the immune system, adipose, liver, and central nervous system. This review summarizes the epidemiologic and experimental evidence between ambient outdoor air pollution and T2DM.
近期针对人类和动物的研究表明，空气污染是2型糖尿病（T2DM）的一个重要风险因素。然而，空气污染介导糖尿病易感性的机制尚未完全明确。尽管多项流行病学研究显示，环境空气污染暴露与T2DM风险之间存在正相关，但一些研究并未发现这种关系。在易感疾病模型中的实验研究确实支持了这种关联，并表明参与T2DM发病机制的组织，如免疫系统、脂肪组织、肝脏和中枢神经系统也牵涉其中。本综述总结了环境室外空气污染与T2DM之间的流行病学和实验证据。
