寻找更佳选择：第三磨牙阻生拔除术中地塞米松与甲泼尼龙的比较
In search of a better option: dexamethasone versus methylprednisolone in third molar impaction surgery.
作者信息
Darawade Dattatraya A, Kumar Santosh, Mehta Rupal, Sharma Anant Raghav, Reddy G Sharaschandra
机构信息
Professor and Head, Department of Oral and Maxillofacial Surgery, Rungta College of Dental Sciences, Bhilai, Chattisgarh, India.
Assistant Professor, Department of Periodontology, Karnavati School of Dentistry, Gandhinagar, Gujarat, India.
出版信息
J Int Oral Health. 2014 Nov-Dec;6(6):14-7.
BACKGROUND
Post-surgical complications like pain, swelling, impaired function cause transient morbidity for the patients leading to refrainment of the treatment. Various preemptive drugs are prescribed to prevent patients from such unpleasant situations. Both dexamethasone and methyl prednisolone can be used for this purpose in surgery of third molar impactions.
MATERIALS AND METHODS
This was a split-mouth study consisting 25 patients having Pell and Gregory's Class II position B bilateral impactions. About 8 mg dexamethasone and 40 mg methyl prednisolone were prescribed randomly 1 hour prior to the surgery. Pain, swelling and trismus were noted on 1(st), 2(nd), 3(rd) and 7(th) day following surgery. Wilcoxon test was used to assess the significance between the parameters.
RESULTS
Reduction in swelling and trismus was found to be significantly more with dexamethasone than methyl prednisolone. However, no statistical significant difference was found in post-operative pain.
CONCLUSION
Dexamethasone can be used as a potent preemptive drug for controlling post-operative complications in the removal of third molar impactions.
背景
术后并发症如疼痛、肿胀、功能受损会给患者带来短暂的不适，导致治疗中断。为防止患者出现此类不愉快情况，会使用各种预防性药物。地塞米松和甲泼尼龙均可用于第三磨牙阻生拔除术中。
材料与方法
这是一项双盲研究，纳入了25例双侧佩尔和格雷戈里II类B位阻生的患者。在手术前1小时随机给予约8毫克地塞米松或40毫克甲泼尼龙。在术后第1、2、3和7天记录疼痛、肿胀和张口受限情况。采用威尔科克森检验评估各参数之间的显著性。
结果
发现地塞米松在减轻肿胀和张口受限方面比甲泼尼龙更显著。然而，术后疼痛方面未发现统计学显著差异。
结论
地塞米松可作为一种有效的预防性药物，用于控制第三磨牙阻生拔除术后的并发症。
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