McEvoy J P, Apperson L J, Appelbaum P S, Ortlip P, Brecosky J, Hammill K, Geller J L, Roth L
Department of Psychiatry, University of Pittsburgh, PA.
J Nerv Ment Dis. 1989 Jan;177(1):43-7. doi: 10.1097/00005053-198901000-00007.
The relationship between insight and acute psychopathology was explored in a group of 52 acutely psychotic, schizophrenic patients. A measure of insight, reflecting patients' recognition of their illness and need for care, was validated against ratings from a semi-structured interview and against assessments of patients' compliance with medication. Contrary to expectations, degree of insight was not consistently related to the severity of acute psychopathology, as measured on two structured scales. Nor did changes in insight during hospitalization vary consistently with changes in acute psychopathology. These data suggest that very little of the deficiency in insight seen in schizophrenic patients is explainable on the basis of acute psychopathological features. The mechanism that accounts for impairment in insight in schizophrenia may be relatively resistant to treatment with neuroleptic medication.
在一组52名急性精神病性精神分裂症患者中,探讨了自知力与急性精神病理学之间的关系。通过一项自知力测量指标来反映患者对自身疾病的认识以及对治疗的需求,并与半结构化访谈的评分以及患者对药物治疗的依从性评估进行了验证。与预期相反,自知力程度与通过两个结构化量表测量的急性精神病理学严重程度并无一致关联。住院期间自知力的变化也与急性精神病理学的变化没有始终一致的差异。这些数据表明,精神分裂症患者中所见的自知力缺陷很少能基于急性精神病理学特征来解释。导致精神分裂症患者自知力受损的机制可能相对难以通过抗精神病药物治疗得到改善。