Joo Jong Kil, Hong Gil Pyo, Han Si Eun, Lee Young Ju, Kim Seung Chul, Kim Chang Woon, Lee Kyu Sup
Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Samsung Changwon Hospital, Changwon, Korea.
J Menopausal Med. 2014 Dec;20(3):126-32. doi: 10.6118/jmm.2014.20.3.126. Epub 2014 Dec 24.
The aim of this study is to investigate the association between serum uric acid level and metabolic syndrome according to menopausal status in Korean women.
A total of 2,241 women who visited to the health promotion center at Pusan National University Hospital from 2010 to 2014 were included in this cross-sectional study. Self-report questionnaires and interviews with healthcare providers were used to assess disease history, medication history, menstrual history and body size measuring. Anthropometric measurements and laboratory results were compared as presence of metabolic syndrome and menopausal status by student-t test. Logistic regression analysis was performed between presence of metabolic syndrome and presumable predictive factors, such as age, menopause and serum uric acid.
The prevalence rate of metabolic syndrome were 7.45% (63/846) in pre-menopausal group and 23.87% (333/1395) in menopausal group. Serum uric acid level was higher in menopausal women than premenopausal women (4.6 ± 1.1 vs. 4.3 ± 0.9. P = 0.000). And, its concentration was also higher in metabolic syndrome than normal women regarding of menopausal statue (premenopause 4.7 ± 1.1 vs. 4.2 ± 0.8, P = 0.001, menopause 4.9 ± 1.3 vs. 4.5 ± 1.0, P = 0.000). Multiple logistic regression analysis showed serum uric acid and age have relationship with metabolic syndrome (OR: 1.453, 95% confidence interval [CI]: 1.074-1.111, P = 0.000; OR: 1.092, 95% CI: 1.305-1.619, P = 0.000).
We could find out some potential of uric acid as predictive factor for metabolic syndrome in premenopausal and menopausal group. Further investigation is required to clarify the relationship between serum uric acid, menopause and metabolic syndrome.
本研究旨在根据韩国女性的绝经状态，调查血清尿酸水平与代谢综合征之间的关联。
本横断面研究纳入了2010年至2014年期间到釜山国立大学医院健康促进中心就诊的2241名女性。通过自我报告问卷和与医疗服务提供者的访谈来评估疾病史、用药史、月经史和身体尺寸测量。通过学生t检验比较人体测量学指标和实验室结果，以分析代谢综合征的存在情况和绝经状态。对代谢综合征的存在情况与年龄、绝经和血清尿酸等可能的预测因素进行逻辑回归分析。
绝经前组代谢综合征的患病率为7.45%（63/846），绝经组为23.87%（333/1395）。绝经后女性的血清尿酸水平高于绝经前女性（4.6±1.1 vs. 4.3±0.9，P = 0.000）。而且，无论绝经状态如何，代谢综合征患者的尿酸浓度也高于正常女性（绝经前4.7±1.1 vs. 4.2±0.8，P = 0.001；绝经后4.9±1.3 vs. 4.5±1.0，P = 0.000）。多元逻辑回归分析显示血清尿酸和年龄与代谢综合征有关（比值比：1.453，95%置信区间[CI]：1.074 - 1.111，P = 0.000；比值比：1.092，95%CI：1.305 - 1.619，P = 0.000）。
我们发现尿酸在绝经前和绝经后组中具有作为代谢综合征预测因素的一些潜力。需要进一步研究以阐明血清尿酸、绝经和代谢综合征之间的关系。
