Hedlund G, Sandberg-Wollheim M, Sjögren H O
Department of Tumor Immunology, Wallenberg Laboratory, University of Lund, Sweden.
Cell Immunol. 1989 Feb;118(2):406-12. doi: 10.1016/0008-8749(89)90388-2.
In this study we confirm earlier reports of an increase of the proportion of T and CD4+ lymphocytes and a decrease of B and CD8+ lymphocytes in cerebrospinal fluid (CSF) as compared to peripheral blood (PB) in MS patients. In addition we now demonstrate that this difference between CSF and PB lymphocyte populations is of the same magnitude in healthy individuals suggesting that it is physiological and not associated with disease. Functionally distinct subsets of the T human helper cell (CD4+) population have previously been defined by the monoclonal antibodies 4B4 (CDw29), Leu-18 (CD45R), and UCHL-1. In the present investigation we demonstrate a selective increase in the proportion of CD4+CDw29+CD45R-UCHL-1+ lymphocytes in CSF as compared to PB of both MS patients and healthy individuals, which strongly indicates that also this enrichment is physiological rather than associated with disease. A possible relationship between this subset of CD4+ lymphocytes and T memory cells is discussed.
在本研究中，我们证实了先前的报道，即与外周血（PB）相比，多发性硬化症（MS）患者脑脊液（CSF）中T淋巴细胞和CD4 +淋巴细胞的比例增加，而B淋巴细胞和CD8 +淋巴细胞的比例降低。此外，我们现在证明，在健康个体中，脑脊液和外周血淋巴细胞群体之间的这种差异幅度相同，这表明它是生理性的，与疾病无关。人类辅助性T细胞（CD4 +）群体中功能不同的亚群先前已通过单克隆抗体4B4（CDw29）、Leu - 18（CD45R）和UCHL - 1进行了定义。在本研究中，我们证明，与MS患者和健康个体的外周血相比，脑脊液中CD4 + CDw29 + CD45R - UCHL - 1 +淋巴细胞的比例有选择性增加，这有力地表明这种富集也是生理性的，而非与疾病相关。本文还讨论了该CD4 +淋巴细胞亚群与T记忆细胞之间可能存在的关系。
