al-Kassab A S, Raziuddin S
Department of Clinical Biochemistry, College of Medicine, King Saud University, Abha, Saudi Arabia.
Clin Exp Immunol. 1990 Aug;81(2):267-71. doi: 10.1111/j.1365-2249.1990.tb03329.x.
The peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus (IDDM) and healthy controls were analysed for the HLA-DR+, interleukin-2 receptor-positive (IL-2R+) activating antigens, and for CD45R+ and CDw29+ subsets from the purified CD4+ and CD8+ T cells populations. Patients with IDDM had an increased percentage of HLA-DR+ and IL-2R+ cells in both CD4+ and CD8+ T cells. However, the percentage of CD4+ CD45R+ suppressor/inducer T cells were decreased and CD4+ CDw29+ helper/inducer T cells increased in all patients with IDDM, compared with healthy controls. Thus, IDDM patients exhibit a deficiency in the CD4+ CD45R+ suppressor/inducer T cell subsets, which is probably related to the autoimmune phenomenon in this disease. In contrast, the percentage of CD8+ CDw29+ T cell subsets showed no major differences between patients with IDDM and controls. An alteration in the CD4+ CD45R+ and CD4+ CDw29+ T cell subsets appears to be a characteristic feature, and may relate to the impaired cell-mediated immunity in IDDM. These data provide new evidence for T cell dysregulation in IDDM.
对胰岛素依赖型糖尿病（IDDM）患者和健康对照者的外周血淋巴细胞进行分析，检测其HLA-DR⁺、白细胞介素-2受体阳性（IL-2R⁺）激活抗原，以及纯化的CD4⁺和CD8⁺T细胞群体中的CD45R⁺和CDw29⁺亚群。IDDM患者的CD4⁺和CD8⁺T细胞中HLA-DR⁺和IL-2R⁺细胞的百分比均增加。然而，与健康对照相比，所有IDDM患者的CD4⁺CD45R⁺抑制/诱导性T细胞百分比降低，而CD4⁺CDw29⁺辅助/诱导性T细胞增加。因此，IDDM患者表现出CD4⁺CD45R⁺抑制/诱导性T细胞亚群缺陷，这可能与该疾病的自身免疫现象有关。相比之下，IDDM患者和对照者之间CD8⁺CDw29⁺T细胞亚群的百分比没有显著差异。CD4⁺CD45R⁺和CD4⁺CDw29⁺T细胞亚群的改变似乎是一个特征性表现，可能与IDDM中细胞介导的免疫受损有关。这些数据为IDDM中T细胞调节异常提供了新的证据。
