Jones Krista L, Granger L Abbigail, Kearney Michael T, da Cunha Anderson F, Cutler Daniel C, Shapiro Meredith E, Tully Thomas N, Shiomitsu Keijiro
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803.
Am J Vet Res. 2015 Feb;76(2):142-8. doi: 10.2460/ajvr.76.2.142.
To use CT-derived measurements to create a ferret-specific formula for body surface area (BSA) to improve chemotherapeutic dosing.
25 adult ferrets (19 live and 6 cadavers).
Live subjects were weighed, and body measurements were obtained by each of 3 observers while ferrets were awake and anesthetized. Computed tomography was performed, and a 3-D surface model was constructed with open-source imaging software, from which BSA was estimated. The CT-derived values were compared with BSA calculated on the basis of the traditional tape method for 6 cadavers. To further validate CT analysis software, 11 geometric shapes were scanned and their CT-derived values compared with those calculated directly via geometric formulas. Agreement between methods of surface area estimation was assessed with linear regression. Ferret-specific formulas for BSA were determined with nonlinear regression models.
Repeatability among the 3 observers was good for all measurements, but some measurements differed significantly between awake and anesthetized ferrets. Excellent agreement was found between measured versus CT-derived surface area of shapes, traditional tape- versus CT-derived BSA of ferret cadavers, and CT-derived BSA of cadavers with and without monitoring equipment. All surface area formulas performed relatively similarly.
CT-derived BSA measurements of ferrets obtained via open-source imaging software were reliable. On the basis of study results, the recommended formula for BSA in ferrets would be 9.94 × (body weight)(2/3); however, this represented a relatively minor difference from the feline-derived formula currently used by most practitioners and would result in little practical change in drug doses.
利用CT测量值创建雪貂特定的体表面积（BSA）公式，以改进化疗给药剂量。
25只成年雪貂（19只活体和6只尸体）。
对活体雪貂进行称重，并在其清醒和麻醉状态下由3名观察者分别进行身体测量。进行计算机断层扫描，并用开源成像软件构建三维表面模型，据此估算体表面积。将CT测量值与基于传统卷尺法计算的6只尸体雪貂的体表面积进行比较。为进一步验证CT分析软件，扫描了11种几何形状，并将其CT测量值与通过几何公式直接计算的值进行比较。用线性回归评估表面积估计方法之间的一致性。用非线性回归模型确定雪貂特定的体表面积公式。
3名观察者之间的所有测量重复性良好，但清醒和麻醉状态下的雪貂之间的一些测量值存在显著差异。在测量的形状表面积与CT测量的表面积、传统卷尺法测量的雪貂尸体体表面积与CT测量的体表面积以及有和没有监测设备的尸体雪貂的CT测量体表面积之间，均发现了极好的一致性。所有表面积公式的表现相对相似。
通过开源成像软件获得的雪貂CT测量体表面积是可靠的。根据研究结果，推荐的雪貂体表面积公式为9.94×（体重）（2/3）；然而，这与大多数从业者目前使用的猫科动物来源的公式相比差异相对较小，并且药物剂量的实际变化不大。
