Itoh Tadashi, Kawabe Mifumi, Nagase Takahiko, Koike Tsuneo, Miyoshi Masafumi, Miyahara Kazuro
Nihon Bioresearch Inc., 6-104 Majima, Fukujucho, Hashima, Gifu 501-6251, Japan.
Animal Medical Center, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Exp Anim. 2018 Nov 1;67(4):527-534. doi: 10.1538/expanim.18-0028. Epub 2018 Jul 12.
The body surface area (BSA) of an organism is one of the important parameters for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying the k value by 2/3 of the power of the body weight (BW) (Meeh's formula). In mathematics, if it is assumed that the density and body shape of the animals are essentially constant, the BSA is proportional to BW. In this study, we measured the BSA and volume (V) of 72 laboratory rabbits (48 males and 24 females of New Zealand White rabbits [NZW]), using a computed tomography scanner. After BSA and V determination, the k value, density, and sphericity were calculated. We analyzed variations in the k value, density, and body shape of laboratory rabbits. The mean k value of the 72 NZW was 11.0. We advocate using Meeh's formula, as follows, for estimating BSA of laboratory rabbits (NZW): 100 × BSA [m] = 11.0 × BW [kg].
生物体的体表面积（BSA）是评估生理功能的重要参数之一。在药物研发中，通过BSA进行标准化是在不同物种间推算剂量的一种合适方法。动物的BSA通常通过将k值乘以体重（BW）幂的2/3来估算（米氏公式）。在数学上，如果假设动物的密度和体型基本恒定，那么BSA与BW成正比。在本研究中，我们使用计算机断层扫描仪测量了72只实验兔（48只雄性和24只雌性新西兰白兔 [NZW]）的BSA和体积（V）。在确定BSA和V后，计算了k值、密度和球形度。我们分析了实验兔的k值、密度和体型的变化。72只NZW的平均k值为11.0。我们提倡使用如下米氏公式来估算实验兔（NZW）的BSA：100 × BSA [平方米] = 11.0 × BW [千克]。
