抗毒蕈碱3型受体抗体用于干燥综合征诊断的Meta分析。

Meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of Sjögren syndrome.

作者信息

Deng Chuiwen, Hu Chaojun, Chen Si, Li Jing, Wen Xiaoting, Wu Ziyan, Li Yuan, Zhang Fengchun, Li Yongzhe

机构信息

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

出版信息

PLoS One. 2015 Jan 28;10(1):e0116744. doi: 10.1371/journal.pone.0116744. eCollection 2015.

PURPOSE

To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS).

METHODS

Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis.

RESULTS

Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92).

CONCLUSION

The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.

目的

进行一项荟萃分析，以评估抗毒蕈碱3型受体（M3R）抗体在干燥综合征（SS）中的诊断价值。

方法

系统检索了两个数据库，即PUBMED和考克兰图书馆。本研究纳入了来自多项研究的约2000名参与者。使用STATA 11.2软件和Meta-DiSc 1.4进行荟萃分析。

结果

荟萃分析纳入了11项研究。合并的诊断比值比（DOR）为13.00（95%可信区间，6.00 - 26.00）。敏感性为0.43（95%可信区间，0.28 - 0.58），特异性为0.95（95%可信区间，0.91 - 0.97）。阳性似然比（LR+）和阴性似然比（LR-）分别为7.90（95%可信区间，4.70 - 13.40）、0.61（95%可信区间，0.46 - 0.79）。曲线下面积（AUC）为0.89（95%可信区间，0.86 - 0.92）。