Ravazzola M, Benoit R, Ling N, Orci L
Institut d'Histologie et d'Embryologie, Genève, Switzerland.
J Clin Invest. 1989 Feb;83(2):362-6. doi: 10.1172/JCI113892.
The three widely distributed peptides derived from prosomatostatin are the original neurohormone somatostatin-14, somatostatin-28, and somatostatin-28(1-12), which are all derived from the COOH terminus of the precursor. Recently a decapeptide derived from the NH2 terminus of the prohormone has been identified in extracts of rat gastric antrum and named antrin. Data now show that in both rats and humans this new molecular form is concentrated in the D cell of the gastrointestinal mucosa together with somatostatin-28(1-12). The highest concentration of antrin immunofluorescent cells is located in the mucosa of the gastric antrum. Ultrastructural studies performed on pyloric D cells using the protein A-gold technique reveals that antrin is present in the same secretory granules as somatostatin-28(1-12) and detectable in one-third of all secretory granules. Acid extracts of rat hepatic portal plasma contain a peptide similar or identical to antrin, indicating that the antral decapeptide circulates in blood.
源自前生长抑素的三种广泛分布的肽分别是原始神经激素生长抑素 - 14、生长抑素 - 28和生长抑素 - 28(1 - 12)，它们均源自前体的COOH末端。最近，在大鼠胃窦提取物中发现了一种源自激素原NH2末端的十肽，并将其命名为胃窦抑素。现在的数据表明，在大鼠和人类中，这种新的分子形式与生长抑素 - 28(1 - 12)一起集中在胃肠道黏膜的D细胞中。胃窦抑素免疫荧光细胞的最高浓度位于胃窦黏膜中。使用蛋白A - 金技术对幽门D细胞进行的超微结构研究表明，胃窦抑素与生长抑素 - 28(1 - 12)存在于相同的分泌颗粒中，并且在所有分泌颗粒的三分之一中可检测到。大鼠肝门静脉血浆的酸提取物中含有一种与胃窦抑素相似或相同的肽，这表明胃窦十肽在血液中循环。
