Argos P, Taylor W L, Minth C D, Dixon J E
J Biol Chem. 1983 Jul 25;258(14):8788-93.
The amino acid and nucleotide sequences have been aligned for five preprosomatostatins: two from catfish, two from anglerfish, and one from rat. The physical characteristics of the aligned residues as well as substitutions in the nucleotide sequences suggest considerable mutability in one of the catfish and anglerfish precursors while three of the preprohormones which give rise to somatostatins-14 are closely related. Although there is a considerable number of amino acid substitutions within the aligned somatostatin-14 precursors, there is a high degree of structural relatedness among them. These results suggest that additional physiological roles for the amino acid sequences outside of the hormone region are likely. The predicted secondary structures of the three somatostatin-14 precursors are dominated by helical and turn configurations which are correlated with observed co- and post-translational processing of the preprohormones.
已对5种前胰岛素原生长抑素的氨基酸和核苷酸序列进行了比对：两种来自鲶鱼，两种来自琵琶鱼，一种来自大鼠。比对后的残基物理特征以及核苷酸序列中的替代表明，鲶鱼和琵琶鱼前体之一具有相当大的变异性，而产生生长抑素-14的三种前激素密切相关。尽管在比对的生长抑素-14前体中有相当数量的氨基酸替代，但它们之间存在高度的结构相关性。这些结果表明，激素区域之外的氨基酸序列可能具有额外的生理作用。三种生长抑素-14前体的预测二级结构主要由螺旋和转角构型主导，这与前激素的共翻译和翻译后加工情况相关。
