Kantak Abhishek A, Marchetti Louis, DeBoef Brenton
Department of Chemistry, University of Rhode Island, 51 Lower College Rd., Kingston, RI 02881, USA.
Chem Commun (Camb). 2015 Feb 28;51(17):3574-7. doi: 10.1039/c4cc10246k.
A new approach for the direct amination of 2-phenylpyridine derivatives using a diphthalimide-iodane and copper triflate has been developed. A series of different 2-phenylpyridine derivatives were aminated with yields up to 88%. Mechanistic investigations indicate that the reaction proceeds via a copper-mediated single electron transfer.
已开发出一种使用二邻苯二甲酰亚胺碘烷和三氟甲磺酸铜对2-苯基吡啶衍生物进行直接胺化的新方法。一系列不同的2-苯基吡啶衍生物被胺化，产率高达88%。机理研究表明，该反应通过铜介导的单电子转移进行。
