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一种基于数字硅光电倍增管和GAGG闪烁体的正电子发射断层扫描(PET)探测器原型。

A PET detector prototype based on digital SiPMs and GAGG scintillators.

作者信息

Schneider Florian R, Shimazoe Kenji, Somlai-Schweiger Ian, Ziegler Sibylle I

机构信息

Nuklearmedizinische Klinik und Poliklinik, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany. Physik Department E18, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany.

出版信息

Phys Med Biol. 2015 Feb 21;60(4):1667-79. doi: 10.1088/0031-9155/60/4/1667. Epub 2015 Jan 29.

Abstract

Silicon Photomultipliers (SiPM) are interesting light sensors for Positron Emission Tomography (PET). The detector signal of analog SiPMs is the total charge of all fired cells. Energy and time information have to be determined with dedicated readout electronics. Philips Digital Photon Counting has developed a SiPM with added electronics on cell level delivering a digital value of the time stamp and number of fired cells. These so called Digital Photon Counters (DPC) are fully digital devices. In this study, the feasibility of using DPCs in combination with LYSO (Lutetium Yttrium Oxyorthosilicate) and GAGG (Gadolinium Aluminum Gallium Garnet) scintillators for PET is tested. Each DPC module has 64 channels with 3.2 × 3.8775 mm(2), comprising 3200 cells each. GAGG is a recently developed scintillator (Zeff = 54, 6.63 g cm(-3), 520 nm peak emission, 46 000 photons MeV(-1), 88 ns (92%) and 230 ns (8%) decay times, non-hygroscopic, chemically and mechanically stable). Individual crystals of 2 × 2 × 6 mm(3) were coupled onto each DPC pixel. LYSO coupled to the DPC results in a coincidence time resolution (CTR) of 171 ps FWHM and an energy resolution of 12.6% FWHM at 511 keV. Using GAGG, coincidence timing is 310 ps FWHM and energy resolution is 8.5% FWHM. A PET detector prototype with 2 DPCs equipped with a GAGG array matching the pixel size (3.2 × 3.8775 × 8 mm(3)) was assembled. To emulate a ring of 10 modules, objects are rotated in the field of view. CTR of the PET is 619 ps and energy resolution is 9.2% FWHM. The iterative MLEM reconstruction is based on system matrices calculated with an analytical detector response function model. A phantom with rods of different diameters filled with (18)F was used for tomographic tests.

摘要

硅光电倍增管(SiPM)是用于正电子发射断层扫描(PET)的有趣的光传感器。模拟SiPM的探测器信号是所有触发单元的总电荷。能量和时间信息必须通过专用的读出电子设备来确定。飞利浦数字光子计数公司开发了一种在单元级别添加了电子设备的SiPM,可提供时间戳和触发单元数量的数字值。这些所谓的数字光子计数器(DPC)是全数字设备。在本研究中,测试了将DPC与LYSO(硅酸镥钇)和GAGG(钆铝镓石榴石)闪烁体结合用于PET的可行性。每个DPC模块有64个通道,尺寸为3.2×3.8775 mm²,每个通道包含3200个单元。GAGG是一种最近开发的闪烁体(有效原子序数Zeff = 54,密度6.63 g/cm³,峰值发射波长520 nm,每兆电子伏特发射46000个光子,衰减时间分别为88 ns(92%)和230 ns(8%),不吸湿,化学和机械稳定性好)。将2×2×6 mm³的单个晶体耦合到每个DPC像素上。LYSO与DPC耦合时,在511 keV下的符合时间分辨率(CTR)为171 ps半高宽,能量分辨率为12.6%半高宽。使用GAGG时,符合定时为310 ps半高宽,能量分辨率为8.5%半高宽。组装了一个带有2个DPC的PET探测器原型,配备了与像素尺寸匹配的GAGG阵列(3.2×3.8775×8 mm³)。为了模拟由10个模块组成的环,在视野中旋转物体。该PET的CTR为619 ps,能量分辨率为9.2%半高宽。迭代最大似然期望最大化(MLEM)重建基于使用解析探测器响应函数模型计算的系统矩阵。使用一个填充有¹⁸F的不同直径棒的体模进行断层扫描测试。

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