Zhang Aizhong, Maki Kara L, Salahura Gheorghe, Kottaiyan Ranjini, Yoon Geunyoung, Hindman Holly B, Aquavella James V, Zavislan James M
University of Rochester Flaum Eye Institute, Ocular Surface Laboratory, Rochester, NY, USA; Institute of Optics, University of Rochester, Rochester, NY, USA.
School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY, USA.
Exp Eye Res. 2015 Mar;132:231-9. doi: 10.1016/j.exer.2015.01.021. Epub 2015 Jan 26.
In this study, we explore the usage of ocular surface temperature (OST) decay patterns to distinguished between dry eye patients with aqueous deficient dry eye (ADDE) and meibomian gland dysfunction (MGD). The OST profiles of 20 dry eye subjects were measured by a long-wave infrared thermal camera in a standardized environment (24 °C, and relative humidity (RH) 40%). The subjects were instructed to blink every 5 s after 20 ∼ 25 min acclimation. Exponential decay curves were fit to the average temperature within a region of the central cornea. We find the MGD subjects have both a higher initial temperature (p < 0.022) and a higher asymptotic temperature (p < 0.007) than the ADDE subjects. We hypothesize the temperature difference among the subpopulations is due to tear volume and heat transfer mechanisms. To study the validity of our claim, we develop a mathematical model, referred to as the thermal impulse perturbation (TIP) model. We conclude that long-wave-infrared thermal imaging is a plausible tool in assisting with the classification of dry eye patient.
在本研究中，我们探讨了眼表温度（OST）衰减模式在区分水液缺乏型干眼（ADDE）患者和睑板腺功能障碍（MGD）患者中的应用。在标准化环境（24°C，相对湿度（RH）40%）下，使用长波红外热像仪测量了20名干眼受试者的OST曲线。在适应20至25分钟后，受试者被要求每5秒眨眼一次。对中央角膜区域内的平均温度拟合指数衰减曲线。我们发现，与ADDE受试者相比，MGD受试者的初始温度更高（p < 0.022），渐近温度也更高（p < 0.007）。我们推测亚组之间的温度差异是由于泪液量和热传递机制所致。为了研究我们这一说法的有效性，我们开发了一个数学模型，称为热脉冲扰动（TIP）模型。我们得出结论，长波红外热成像在辅助干眼患者分类方面是一种可行的工具。
