具有适当结构刚性的无环L-苏氨醇核酸（L-aTNA）与DNA和RNA交叉配对。

Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA.

作者信息

Murayama Keiji, Kashida Hiromu, Asanuma Hiroyuki

机构信息

Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

出版信息

Chem Commun (Camb). 2015 Apr 18;51(30):6500-3. doi: 10.1039/c4cc09244a.

DOI:10.1039/c4cc09244a

PMID:25633432

Abstract

We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

摘要

我们报告了一种新型人工核酸——无环L-苏氨醇核酸（L-aTNA）的杂交特性。L-aTNA与DNA和RNA形成的双链体比D-aTNA或丝氨醇核酸（SNA）更稳定，因为L型的刚性更适合与天然核酸相互作用。