Emma-Okon B O, Onayade A A, Adegoke A O, Soyinka J O, Ademigbuji E A
Niger Postgrad Med J. 2014 Dec;21(4):290-3.
To describe the pattern of lipid profile of members of staff of a tertiary education institution in South-West Nigeria with a view to assessing risk of cardiovascular disease among them.
One hundred and ninety three (193) members of staff of the Institution were involved in the study. Questionnaires were administered to obtain information on demographic characteristics and medical history of respondents. Weight, height and blood pressure of participants were measured and the Body Mass Index (BMI) calculated. Fasting plasma lipid profile parameters--Total cholesterol (TC), High Density Lipoprotein cholesterol (HDL-C) , Low Density Lipoprotein cholesterol (LDL-C) and Triglycerides (TG)) were also determined in all the participants using standard assay methods.
Mean TC, HDL-C, LDL-C and TG were 4.04 mmol/L, 1.63 mmol/L, 1.98 mmol/L and 0.92 mmol/L respectively . Mean BMI was 25.98 kg/m2. Twenty-eight (14.5%) participants had mean cholesterol values e" 5.2 mM/L, 19 men had HDL values<1.0 mM/L and 28 women had HDL values<1.3 mM/L (making a total of 24.3% of the study population). Twenty (10.4%) had LDL cholesterol e"3.3 mM/L, while 14 (7.3 %) had triglyceride valuese" 1.7 mM/L. One hundred and thirty one (67.8%) participants had values of all lipid parameters within reference range while 62 (32.8%) had abnormality in 1 or more of the parameters. Sixty two participants (32.1%) were overweight while 45 (23.3%) were obese. Statistically significant differences were found when TG and BMI levels of male participants were compared with those of their female counterparts. Abnormalities in lipid profile parameters were found mostly in participants who were 40 years and above. Age of participants correlated positively with total cholesterol and LDL cholesterol levels while LDL-C levels correlated negatively with HDL levels.
A significant proportion of the population had abnormality in one or more Lipid profile parameters, the most common being low HDL cholesterol levels. A considerable number of participants were also either overweight or obese. Most of the abnormalities in lipid profile were found in participants e" 40 years. The study underscores a need to sensitise members of the community to regular lipid profile check up .
描述尼日利亚西南部一所高等教育机构工作人员的血脂谱模式，以评估他们患心血管疾病的风险。
该机构的193名工作人员参与了这项研究。通过问卷调查获取受访者的人口统计学特征和病史信息。测量参与者的体重、身高和血压，并计算体重指数（BMI）。还使用标准检测方法测定了所有参与者的空腹血脂谱参数——总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）。
平均TC、HDL-C、LDL-C和TG分别为4.04 mmol/L、1.63 mmol/L、1.98 mmol/L和0.92 mmol/L。平均BMI为25.98 kg/m²。28名（14.5%）参与者的平均胆固醇值≥5.2 mM/L，19名男性的HDL值<1.0 mM/L，28名女性的HDL值<1.3 mM/L（占研究人群的24.3%）。20名（10.4%）参与者的LDL胆固醇≥3.3 mM/L，而14名（7.3%）参与者的甘油三酯值≥1.7 mM/L。131名（67.8%）参与者的所有血脂参数值均在参考范围内，而62名（32.8%）参与者有1项或多项参数异常。62名参与者（32.1%）超重，45名（23.3%）肥胖。比较男性参与者和女性参与者的TG和BMI水平时，发现有统计学显著差异。血脂谱参数异常大多出现在40岁及以上的参与者中。参与者的年龄与总胆固醇和LDL胆固醇水平呈正相关，而LDL-C水平与HDL水平呈负相关。
相当一部分人群有一项或多项血脂谱参数异常，最常见的是HDL胆固醇水平低。相当数量的参与者超重或肥胖。大多数血脂谱异常出现在40岁及以上的参与者中。该研究强调需要提高社区成员对定期血脂谱检查的认识。
